Childhood cardiometabolic risk factors associated with the perinatal environment of the maternal–paternal–child triad

IF 2.7 3区医学 Q1 PEDIATRICS Pediatric Obesity Pub Date : 2024-08-25 DOI:10.1111/ijpo.13162

Diamond L. McGehee, Jessica L. Saben, Clark R. Sims, Donald Turner, Keshari M. Thakali, Eva C. Diaz, Sarah R. Sobik, Timothy Edwards, Rebecca A. Krukowski, D. Keith Williams, Elisabet Børsheim, Aline Andres

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Abstract

Introduction

Clustering of cardiometabolic risk factors in childhood significantly increases the risk of atherosclerotic cardiovascular disease later in life. Identification of modifiable parental factors that contribute to offspring cardiometabolic health is critical for the prevention of disease. The objective was to identify factors associated with child cardiometabolic risk factors at age 5 years.

Methods

Triads from a longitudinal cohort were recalled at 5 years (n = 68). Dietary intake, anthropometrics, physical activity and serum-based risk factors were collected. Best subset selection, linear and logistic regressions were used to identify triad variables associated with increased risk of cardiometabolic risk factor clustering at age 5 years.

Results

In this cohort, best subset modelling revealed that increased paternal fat mass, serum low-density lipoproteins and triglycerides, maternal dietary added sugar and being female were associated with increased odds of offspring having two or more cardiometabolic risk factors at age 5 years.

Conclusions

Dietary and exercise interventions prior to conception targeting paternal adiposity and dyslipidaemia as well as maternal dietary habits could decrease children's cardiometabolic risk in later life.

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与母亲-父亲-孩子三方围产期环境相关的儿童心脏代谢风险因素。

简介儿童时期心脏代谢风险因素的聚集会显著增加日后罹患动脉粥样硬化性心血管疾病的风险。确定可改变导致后代心脏代谢健康的父母因素对于预防疾病至关重要。该研究旨在确定与 5 岁儿童心脏代谢风险因素相关的因素：方法：对一个纵向队列中的三胞胎进行 5 岁时的回忆（n = 68）。收集了膳食摄入、人体测量、体力活动和血清风险因素。采用最佳子集选择、线性回归和逻辑回归来确定与 5 岁时心脏代谢风险因素聚集风险增加有关的三联变量：在该队列中，最佳子集建模显示，父亲脂肪量、血清低密度脂蛋白和甘油三酯、母亲膳食中添加的糖和女性的增加与后代在 5 岁时出现两种或两种以上心脏代谢风险因素的几率增加有关：结论：在受孕前针对父亲的脂肪和血脂异常以及母亲的饮食习惯进行饮食和运动干预，可降低儿童日后的心脏代谢风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.