Association of polyomavirus infection with lung cancer: A systematic review and meta-analysis

IF 2.9 4区医学 Q2 PATHOLOGY Pathology, research and practice Pub Date : 2024-08-10 DOI:10.1016/j.prp.2024.155521

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Abstract

Aim

The objective of this study was to investigate the pooled prevalence and possible association between polyomavirus infection and lung cancer.

Methods

A systematic publication search was conducted by identifying relevant cross-sectional and case-control studies from major online databases. Heterogeneity, OR, and corresponding 95 % CI were applied to all studies through meta-analysis and forest plot. Random effects models were used to calculate the overall pooled prevalence. Visual inspection of a funnel plot plotting the log-transformed OR and its associated standard error of the log (OR) was combined with the Begg and Egger test to examine the presence and influence of publication bias. Analyzes were performed using Stata software v.14.1.

Results

23 articles (33 datasets) were included in the meta-analysis, of which 14 datasets were case/control and the rest were cross-sectional studies. The pooled polyomavirus infection rate in lung cancer patients was 0.06 % (0.02–0.11 %). In subgroup analysis, the pooled prevalence of JCV, MCPyV, KI, SV40, BKV, WU, MU, and STL was 21 %, 7 %, 6 %, 2 %, 0 %, 0 %, 0 %, and 0 % respectively. An association has been found between polyomavirus infection and lung cancer [summary OR 6.33 (95 % CI (1.76–22.77); I2=67.45 %)]. The subgroup analysis, based on the virus type, showed a strong association between MCPyV and lung cancer [summary OR 13.61 (95 % CI 2.41–76.59; I2=40.0 %)]. despite the high prevalence of JCV DNA in lung cancer tissue, analysis of case-control studies showed that JCV is not associated with lung cancer and does not increase the risk of lung cancer.

Conclusion

This study showed a significant association between polyomaviruses infection with lung cancer. The results also revealed a pooled prevalence of 6 % for polyomaviruses in lung tumor patients. Altogether, the findings of the present work suggest that Merkel cell polyomavirus infection is a potential risk factor for lung cancer.

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多瘤病毒感染与肺癌的关系：系统回顾和荟萃分析。

目的：本研究旨在调查多瘤病毒感染与肺癌之间的总体流行率和可能的关联：通过从主要在线数据库中查找相关的横断面研究和病例对照研究，进行了系统的文献检索。通过荟萃分析和森林图对所有研究进行异质性、OR 和相应的 95 % CI 分析。随机效应模型用于计算总体汇总患病率。在绘制对数变换 OR 及其相关对数标准误差（OR）的漏斗图时，结合 Begg 和 Egger 检验进行目测，以检查是否存在发表偏倚及其影响。结果：23 篇文章（33 个数据集）被纳入荟萃分析，其中 14 个数据集为病例/对照研究，其余为横断面研究。汇总的肺癌患者多瘤病毒感染率为 0.06%（0.02%-0.11%）。在亚组分析中，JCV、MCPyV、KI、SV40、BKV、WU、MU 和 STL 的总感染率分别为 21%、7%、6%、2%、0%、0%、0% 和 0%。多瘤病毒感染与肺癌之间存在关联[总 OR 6.33（95 % CI (1.76-22.77)；I2=67.45 %]。尽管肺癌组织中 JCV DNA 的流行率很高，但病例对照研究分析表明，JCV 与肺癌无关，也不会增加患肺癌的风险：结论：这项研究表明，多瘤病毒感染与肺癌之间存在明显关联。结论：本研究表明，多瘤病毒感染与肺癌之间存在显著关联，研究结果还显示，肺部肿瘤患者中多瘤病毒的总感染率为 6%。总之，本研究结果表明，梅克尔细胞多瘤病毒感染是肺癌的潜在危险因素。

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.