Current advancements in nanotechnology for stem cells.

IF 12.5 2区 医学 Q1 SURGERY International journal of surgery Pub Date : 2024-09-05 DOI:10.1097/JS9.0000000000002082
P Thamarai, S Karishma, R Kamalesh, Alan Shaji, A Saravanan, Shabana Bibi, A S Vickram, Hitesh Chopra, Rimah Abdullah Saleem, Khalaf F Alsharif, Abdulrahman Theyab, Mohamed Kamel, Mariam K Alamoudi, Ajoy Kumer, Shivani Chopra, Mohamed M Abdel-Daim
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Abstract

Stem cell therapy has emerged as a promising approach for regenerative medicine, offering potential treatments for a wide range of diseases and injuries. Although stem cell therapy has great promise, several obstacles have prevented its broad clinical adoption. The effectiveness of therapy has been inhibited by problems such as ineffective stem cell differentiation, low post-transplantation survival rates, and restricted control over stem cell behaviour. Furthermore, the implementation of stem cell therapies is further complicated by the possibility of immunological rejection and cancer. Innovative strategies that provide precise control over stem cell characteristics and maximize their therapeutic potential are desperately needed to overcome these obstacles. Recent studies have shown that the effectiveness of stem cell treatments can be greatly increased by nanoscale advances. By establishing an ideal microenvironment and precisely offering growth factors, nanomaterials such as nanoparticles, nanocomposites, and quantum dots have been demonstrated to improve stem cell differentiation and proliferation. This article provides an overview of the recent trends and applications of nanoscale innovations in the context of stem cell therapy. The recent development of precision medicine has been facilitated by the incorporation of nanotechnology into stem cell therapy. The ability to manipulate stem cells at the nanoscale offers unprecedented control over their behavior and function, opening up exciting possibilities for personalized and highly effective therapeutic interventions. This review paper highlights the recent trends and applications of nanotechnology in advancing stem cell therapy, showcasing its potential to revolutionize regenerative medicine.

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干细胞纳米技术的最新进展。
干细胞疗法已成为一种前景广阔的再生医学方法,可治疗多种疾病和损伤。虽然干细胞疗法大有可为,但有几个障碍阻碍了它在临床上的广泛应用。干细胞分化效果不佳、移植后存活率低、干细胞行为控制受限等问题抑制了治疗的有效性。此外,干细胞疗法的实施还因可能出现免疫排斥反应和癌症而变得更加复杂。为了克服这些障碍,我们迫切需要能够精确控制干细胞特性并最大限度发挥其治疗潜力的创新策略。最近的研究表明,纳米技术的进步可以大大提高干细胞治疗的有效性。通过建立理想的微环境和精确提供生长因子,纳米粒子、纳米复合材料和量子点等纳米材料已被证明可改善干细胞分化和增殖。本文概述了纳米创新在干细胞治疗方面的最新趋势和应用。纳米技术融入干细胞疗法,促进了精准医疗的最新发展。在纳米尺度上操纵干细胞的能力为干细胞的行为和功能提供了前所未有的控制,为个性化和高效的治疗干预开辟了令人兴奋的可能性。这篇综述论文重点介绍了纳米技术在推进干细胞疗法方面的最新趋势和应用,展示了纳米技术彻底改变再生医学的潜力。
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来源期刊
CiteScore
17.70
自引率
3.30%
发文量
0
审稿时长
6-12 weeks
期刊介绍: The International Journal of Surgery (IJS) has a broad scope, encompassing all surgical specialties. Its primary objective is to facilitate the exchange of crucial ideas and lines of thought between and across these specialties.By doing so, the journal aims to counter the growing trend of increasing sub-specialization, which can result in "tunnel-vision" and the isolation of significant surgical advancements within specific specialties.
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