A Higher-Protein, Energy Restriction Diet Containing 4 Servings of Fresh, Lean Beef per Day Does Not Negatively Influence Circulating miRNAs Associated with Cardiometabolic Disease Risk in Women with Overweight

IF 3.8 Q2 NUTRITION & DIETETICS Current Developments in Nutrition Pub Date : 2024-09-01 DOI:10.1016/j.cdnut.2024.104442
Kamille A Piacquadio , Jess A Gwin , Heather J Leidy
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Abstract

This study examined the acute effects of 7-d energy restriction normal-protein (NP; ∼15% of daily intake as protein) compared with higher-protein (HP; ∼38% of daily intake as protein) diets varying in quantities of fresh, lean beef on circulating miRNA expression associated with cardiometabolic disease in 16 women with overweight (mean ± SD; age: 35 ± 8.7 y; body mass index: 28.5 ± 1.9 kg/m2). Fasting blood samples were collected at the end of each diet for miRNA expression, glucose, insulin, adiponectin, C-reactive protein (CRP), and IL-6. Of the 12 surveyed, 10 miRNAs (miR-320a-3p, miR-146a-5p, miR-150-5p, miR-423-5p, miR-122-5p, miR-223-3p, miR-199a-5p, miR-214-3p, miR-24-3p, and miR-126-3p) were detected. Several miRNAs were associated with fasting CRP (i.e., miR-150-5p, miR-24-3p, miR-423-5p; all P < 0.05). miR-423-5p was also associated with fasting glucose, IL-6, and homeostasis model assessment 2 %β cell function (all, P < 0.05). No differences in miRNA expression were identified between diets. These data suggest that fresh, lean beef in a short-term HP, energy restriction diet does not negatively influence circulating miRNAs associated with cardiometabolic disease in women.

This trial was registered at clinicaltrials.gov as NCT02614729.

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每天摄入 4 份新鲜瘦牛肉的高蛋白、能量限制饮食不会对超重女性与心脏代谢疾病风险相关的循环 miRNA 产生负面影响
本研究以 16 名超重女性(平均值 ± SD;年龄:35 ± 8.7 岁;体重指数:28.5 ± 1.9 kg/m2)为研究对象,比较了 7 天能量限制正常蛋白质(NP;蛋白质含量占每日摄入量的 15%)与高蛋白(HP;蛋白质含量占每日摄入量的 38%)饮食(新鲜瘦牛肉的数量不同)对与心脏代谢疾病相关的循环 miRNA 表达的急性影响。在每次饮食结束时采集空腹血样,检测 miRNA 表达、葡萄糖、胰岛素、脂肪连素、C 反应蛋白 (CRP) 和 IL-6。在 12 项调查中,检测到了 10 个 miRNA(miR-320a-3p、miR-146a-5p、miR-150-5p、miR-423-5p、miR-122-5p、miR-223-3p、miR-199a-5p、miR-214-3p、miR-24-3p 和 miR-126-3p)。一些 miRNA 与空腹 CRP 相关(即 miR-150-5p、miR-24-3p、miR-423-5p;均为 P < 0.05)。miR-423-5p 还与空腹血糖、IL-6 和稳态模型评估 2 %β 细胞功能相关(均为 P < 0.05)。不同饮食的 miRNA 表达没有差异。这些数据表明,在短期HP、能量限制饮食中摄入新鲜瘦牛肉不会对与女性心脏代谢疾病相关的循环miRNA产生负面影响。该试验已在clinicaltrials.gov上注册,编号为NCT02614729。
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来源期刊
Current Developments in Nutrition
Current Developments in Nutrition NUTRITION & DIETETICS-
CiteScore
5.30
自引率
4.20%
发文量
1327
审稿时长
8 weeks
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