Differentiated Thyroid Carcinoma Long-Term Prognostic Factors.

IF 1.6 Q4 ONCOLOGY International Journal of Surgical Oncology Pub Date : 2024-09-10 eCollection Date: 2024-01-01 DOI:10.1155/2024/1067447
Pacheco-Ojeda Luis, Martínez-Jaramillo Ana Lucía, Romo-Castillo Hugo, Recalde-Maldonado Ramiro, Cañizares-Quisiguiña Stalin
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Abstract

Introduction: Thyroid cancer is the most common cancer in women in Ecuador.

Objective: The aim of this study was to determine the demographics and clinical and treatment variables of patients with papillary or follicular thyroid cancer, referred to as differentiated thyroid cancer (DTC), treated at a third-level hospital in Quito, Ecuador.

Methods: We reviewed retrospectively the medical records of patients with DTC, who underwent surgical treatment, from 1990 to 2019. Data included demographics, pathological information, clinical stage, type of surgery, and radioactive iodine (RAI) adjuvant therapy. Patients were monitored for up to 29 years (median follow-up time 6.9 years).

Results: The corrected overall 5-, 10-, 20-, and 30-year survival rates (Kaplan-Meier) were 93%, 85%, 70%, and 63%, respectively. On univariate analysis, age, histological type, tumor grade, histological variants, capsular invasion, vascular invasion, tumor size, clinical stage, distant metastases at diagnosis, surgical margins, extrathyroidal invasion, radioactive iodine adjuvant treatment, and locoregional recurrence were found to be significant prognostic factors. In a multivariate analysis, the following independent variables: age over 55 years, extrathyroidal spread, metastasis at diagnosis, and stage II to IV raised the risk of death (hazard risk) (HR).

Conclusions: Age over 55 years, extrathyroidal spread, metastasis at diagnosis, and advanced clinical stage were found to have a harmful prognosis and an increased risk of death in a series of Ecuadorian patients surgically treated for a DTC.

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分化型甲状腺癌的长期预后因素
简介:甲状腺癌是厄瓜多尔妇女最常见的癌症:甲状腺癌是厄瓜多尔妇女最常见的癌症:本研究旨在确定在厄瓜多尔基多一家三级医院接受治疗的甲状腺乳头状癌或滤泡状癌(简称分化型甲状腺癌(DTC))患者的人口统计学特征、临床和治疗变量:我们回顾性地查阅了1990年至2019年接受手术治疗的DTC患者的病历。数据包括人口统计学、病理学信息、临床分期、手术类型和放射性碘(RAI)辅助治疗。对患者进行了长达29年的监测(中位随访时间为6.9年):经校正的5年、10年、20年和30年总生存率(Kaplan-Meier)分别为93%、85%、70%和63%。单变量分析发现,年龄、组织学类型、肿瘤分级、组织学变异、囊腔侵犯、血管侵犯、肿瘤大小、临床分期、诊断时远处转移、手术切缘、甲状腺外侵犯、放射性碘辅助治疗和局部复发是重要的预后因素。在多变量分析中,以下自变量提高了死亡风险(危险风险):55岁以上、甲状腺外扩散、诊断时的转移以及II期至IV期:结论:在一系列接受DTC手术治疗的厄瓜多尔患者中,年龄超过55岁、甲状腺外转移、确诊时有转移以及临床分期较晚都会对预后不利并增加死亡风险。
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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
期刊最新文献
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