Association between Higher Intake of Flavonols and Lignans and Better Mood: Evidence from Dietary and Biomarker Evaluation in Healthy Individuals

IF 4.5 2区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Molecular Nutrition & Food Research Pub Date : 2024-09-30 DOI:10.1002/mnfr.202400112

Xuemei Ma, Yifan Xu, Yong Li, Rachel Gibson, Claire Williams, Andrew J. Lawrence, Chiara Nosarti, Paola Dazzan, Ana Rodriguez-Mateos

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Abstract

Scope

The aim of this study is to investigate associations between (poly)phenol consumption, circulating (poly)phenol metabolites, and mood states in healthy individuals.

Methods and results

The study included 333 healthy individuals. Mood state was assessed with the Positive and Negative Affect Schedule questionnaire. Dietary (poly)phenol intake was estimated matching food consumption data collected using a Food Frequency Questionnaire(FFQ) with a comprehensive in-house (poly)phenol database. A total of 102 (poly)phenol metabolites were quantified in fasting plasma and 24 h urine samples by Liquid Chromatography-Mass Spectrometry using a validated method. A higher intake of lignans, flavanones, and flavonols estimated from FFQs was associated with positive mood after adjusting for age and sex (β: 0.118 to 0.134). A total of 11 urinary (poly)phenol metabolites, including lignan and flavonol metabolites were associated with less negative mood (β: −0.387 to −0.205). No association was found between mood and plasma (poly)phenols.

Conclusion

A higher consumption of lignans flavanones and flavonols is associated with a better mood, while certain urinary metabolites are associated with less negative mood. The lack of associations between fasting plasma (poly)phenols and mood may be due to their transient nature incirculation compared with 24 h urinary metabolites, which reflect longer-term exposure.

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较高的黄酮醇和木酚素摄入量与较好的情绪之间的关系：健康人的膳食和生物标志物评估证据。

研究范围本研究旨在调查健康人的（多）酚摄入量、循环（多）酚代谢物与情绪状态之间的关联：研究对象包括 333 名健康人。情绪状态通过积极和消极情绪表问卷进行评估。膳食中（多）酚的摄入量是通过食物频率调查表（FFQ）收集的食物消耗量数据与全面的内部（多）酚数据库进行比对估算得出的。采用经过验证的方法，通过液相色谱-质谱法对空腹血浆和 24 小时尿液样本中的 102 种（多）酚代谢物进行了定量分析。在对年龄和性别进行调整后，根据 FFQs 估算的较高木酚素、黄烷酮和黄酮醇摄入量与积极情绪相关（β：0.118 至 0.134）。共有 11 种尿（多）酚代谢物（包括木质素和黄酮醇代谢物）与较低的消极情绪相关（β：-0.387 至 -0.205）。情绪与血浆（多）酚之间没有关联：结论：摄入较多的木脂素黄酮和黄酮醇与较好的情绪有关，而某些尿液代谢物与较少的负面情绪有关。空腹血浆（多）酚与情绪之间缺乏关联可能是由于其在血液循环中的短暂性，而 24 小时尿液代谢物则反映了较长时间的暴露。

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来源期刊

Molecular Nutrition & Food Research 工程技术-食品科技

CiteScore

8.70

自引率

1.90%

发文量

250

审稿时长

1.7 months

期刊介绍： Molecular Nutrition & Food Research is a primary research journal devoted to health, safety and all aspects of molecular nutrition such as nutritional biochemistry, nutrigenomics and metabolomics aiming to link the information arising from related disciplines: Bioactivity: Nutritional and medical effects of food constituents including bioavailability and kinetics. Immunology: Understanding the interactions of food and the immune system. Microbiology: Food spoilage, food pathogens, chemical and physical approaches of fermented foods and novel microbial processes. Chemistry: Isolation and analysis of bioactive food ingredients while considering environmental aspects.