Tracking the Helicobacter pylori Epidemic in Adults and Children in China

IF 4.3 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Helicobacter Pub Date : 2024-09-28 DOI:10.1111/hel.13139
Zixing Wang, Yaoda Hu, Ran Fei, Wei Han, Xiaoxiao Wang, Dongbo Chen, Shaoping She
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引用次数: 0

Abstract

Background

The Helicobacter pylori epidemic in China accounts for up to a third of gastric cancers worldwide. We aim to monitor the temporal and spatial dynamics of H. pylori infection in both adults and children across China.

Materials and Methods

We developed a surveillance system consisting of a data collection component that harnessed survey reports in natural populations and an analysis component that accounted for the differences in survey time and location, population age structure, and H. pylori detection method. System outputs were estimates of the prevalence of H. pylori in adults and children (aged ≤ 14 years) presented at three hierarchical levels (regional, provincial, and prefectural).

Results

The overall prevalence of H. pylori infection declined sharply in adults (63.3%, 52.5%, 43.4%, and 38.7%) and less sharply in children (23.1%, 26.1%, 16.0%, and 15.7%) in 1983–1999, 2000–2009, 2010–2014, and 2015–2019, respectively. The changes were asynchronous across regions, with the most marked declines in the Northwest, the Hong Kong-Macao-Taiwan region, and the East. We estimated that 457.6 million adults and 44.5 million children have been infected with H. pylori, with cross-province disparities in prevalence ranging from 24.3% to 69.3% among adults and 2.9% to 46.3% among children. In general, the risk level of gastric cancer increased as the prevalence of H. pylori increased. The correlation was statistically significant for both adult men (Spearman coefficient of correlation: 0.393, p = 0.0146) and women (0.470, p = 0.0029).

Conclusions

The tracking system would be important for the continuous and stratified tracking of the Helicobacter pylori epidemic across China and can be used to furnish an evidence base for the formulation of tailored prevention strategies.

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追踪幽门螺杆菌在中国成人和儿童中的流行情况。
背景:幽门螺杆菌在中国的流行占全球胃癌发病率的三分之一。我们旨在监测中国成人和儿童幽门螺杆菌感染的时空动态:我们开发了一个监测系统,该系统由数据收集部分和分析部分组成,前者利用自然人群的调查报告,后者考虑了调查时间和地点、人群年龄结构以及幽门螺杆菌检测方法的差异。系统的输出结果是成人和儿童(年龄小于 14 岁)幽门螺杆菌感染率的估计值,按三个层次(地区、省和都道府县)显示:1983-1999年、2000-2009年、2010-2014年和2015-2019年,成人幽门螺杆菌感染率分别为63.3%、52.5%、43.4%和38.7%,儿童感染率分别为23.1%、26.1%、16.0%和15.7%。各地区的变化并不同步,西北地区、港澳台地区和东部地区的下降最为明显。我们估计有 4.576 亿成人和 4450 万儿童感染了幽门螺杆菌,成人感染率的跨省差异从 24.3% 到 69.3%,儿童感染率的跨省差异从 2.9% 到 46.3%。一般来说,幽门螺杆菌感染率越高,患胃癌的风险就越大。成年男性(斯皮尔曼相关系数:0.393,P = 0.0146)和女性(0.470,P = 0.0029)的相关性在统计学上都很显著:结论:幽门螺杆菌追踪系统对持续、分层追踪幽门螺杆菌在中国的流行情况具有重要意义,可为制定有针对性的预防策略提供证据基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Helicobacter
Helicobacter 医学-微生物学
CiteScore
8.40
自引率
9.10%
发文量
76
审稿时长
2 months
期刊介绍: Helicobacter is edited by Professor David Y Graham. The editorial and peer review process is an independent process. Whenever there is a conflict of interest, the editor and editorial board will declare their interests and affiliations. Helicobacter recognises the critical role that has been established for Helicobacter pylori in peptic ulcer, gastric adenocarcinoma, and primary gastric lymphoma. As new helicobacter species are now regularly being discovered, Helicobacter covers the entire range of helicobacter research, increasing communication among the fields of gastroenterology; microbiology; vaccine development; laboratory animal science.
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