A population-scale analysis of 36 gut microbiome studies reveals universal species signatures for common diseases.

IF 7.8 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY npj Biofilms and Microbiomes Pub Date : 2024-10-01 DOI:10.1038/s41522-024-00567-9
Wen Sun, Yue Zhang, Ruochun Guo, Shanshan Sha, Changming Chen, Hayan Ullah, Yan Zhang, Jie Ma, Wei You, Jinxin Meng, Qingbo Lv, Lin Cheng, Shao Fan, Rui Li, Xiaohong Mu, Shenghui Li, Qiulong Yan
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Abstract

The gut microbiome has been implicated in various human diseases, though findings across studies have shown considerable variability. In this study, we reanalyzed 6314 publicly available fecal metagenomes from 36 case-control studies on different diseases to investigate microbial diversity and disease-shared signatures. Using a unified analysis pipeline, we observed reduced microbial diversity in many diseases, while some exhibited increased diversity. Significant alterations in microbial communities were detected across most diseases. A meta-analysis identified 277 disease-associated gut species, including numerous opportunistic pathogens enriched in patients and a depletion of beneficial microbes. A random forest classifier based on these signatures achieved high accuracy in distinguishing diseased individuals from controls (AUC = 0.776) and high-risk patients from controls (AUC = 0.825), and it also performed well in external cohorts. These results offer insights into the gut microbiome's role in common diseases in the Chinese population and will guide personalized disease management strategies.

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对 36 项肠道微生物组研究进行的群体规模分析揭示了常见疾病的普遍物种特征。
肠道微生物组与多种人类疾病有关,但不同研究的结果显示出相当大的差异。在这项研究中,我们重新分析了来自 36 项不同疾病病例对照研究的 6314 个公开的粪便元基因组,以研究微生物多样性和疾病共享特征。利用统一的分析管道,我们观察到许多疾病的微生物多样性降低了,而有些疾病的微生物多样性增加了。在大多数疾病中都发现了微生物群落的显著变化。一项荟萃分析确定了 277 种与疾病相关的肠道物种,其中包括患者体内富集的大量机会性病原体以及有益微生物的减少。基于这些特征的随机森林分类器在区分患病个体与对照组(AUC = 0.776)和高危患者与对照组(AUC = 0.825)方面具有很高的准确性,而且在外部队列中也表现良好。这些结果有助于深入了解肠道微生物组在中国人群常见疾病中的作用,并将为个性化疾病管理策略提供指导。
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来源期刊
npj Biofilms and Microbiomes
npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology
CiteScore
12.10
自引率
3.30%
发文量
91
审稿时长
9 weeks
期刊介绍: npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.
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