Chan Huang, Le Liang, Yong-qing Liu, Mei Han, Xue-lin Wang, Xiao-hua Cai, Guang-long Zou
{"title":"Preparation and multipurpose applications of nitrogen-sulfur doped carbon dots fluorescent probe for Ga3+ and riboflavin (VB2) detection","authors":"Chan Huang, Le Liang, Yong-qing Liu, Mei Han, Xue-lin Wang, Xiao-hua Cai, Guang-long Zou","doi":"10.1016/j.microc.2024.111759","DOIUrl":null,"url":null,"abstract":"<div><div>Designing versatile carbon quantum dots (CDs) with excellent sensitivity and unique function as efficient fluorescent probe for detection of specific substance from cheap and readily available substrates is still a crucial challenge. A novel nitrogen-sulfur doped carbon dots (N, S-CDs) with blue-green fluorescent emission derived from lactose and 4-amino-3-hydroxy-1-naphthalenesulfonic acid (AHNS) was facilely synthesized by one-step hydrothermal process. The obtained N, S-CDs with graphene structure exhibited good water solubility, excellent biocompatibility, satisfactory stability and striking optical properties. The surface of N, S-CDs is modified by various functional groups which are helpful to combine with Ga<sup>3+</sup> in the form of complexes N, S-CDs-Ga<sup>3+</sup> to considerably enhance the fluorescence emission peak of N, S-CDs, further improving the selectivity and sensitivity of Ga<sup>3+</sup> detection with the detection limit of 0.133 μM. At the meantime, N, S-CDs can cause yellow fluorescence quenching of riboflavin (VB<sub>2</sub>) with the detection limit of 0.121 μM under the concentration range from 1.000-20.000 μM. The possible mechanism is the functional groups at the surface of N, S-CDs combined with the hydroxyl, amino and carbonyl group of VB<sub>2</sub> by protonation and hydrogen bonds. Further investigations for practical applications demonstrated that N, S-CDs has good prospects in Ga<sup>3+</sup>ananlysis and detection of VB<sub>2</sub> in food. Moreover, N, S-CDs can be used to determine whether there is Ga<sup>3+</sup> in transferrin, which can indirectly inhibit the growth of cancer cells through the influence on transporting iron ion. Therefore, it is profitable for preliminary diagnosis and treatment of cancer cells in the field of biomedicine.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111759"},"PeriodicalIF":4.9000,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microchemical Journal","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0026265X2401871X","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Designing versatile carbon quantum dots (CDs) with excellent sensitivity and unique function as efficient fluorescent probe for detection of specific substance from cheap and readily available substrates is still a crucial challenge. A novel nitrogen-sulfur doped carbon dots (N, S-CDs) with blue-green fluorescent emission derived from lactose and 4-amino-3-hydroxy-1-naphthalenesulfonic acid (AHNS) was facilely synthesized by one-step hydrothermal process. The obtained N, S-CDs with graphene structure exhibited good water solubility, excellent biocompatibility, satisfactory stability and striking optical properties. The surface of N, S-CDs is modified by various functional groups which are helpful to combine with Ga3+ in the form of complexes N, S-CDs-Ga3+ to considerably enhance the fluorescence emission peak of N, S-CDs, further improving the selectivity and sensitivity of Ga3+ detection with the detection limit of 0.133 μM. At the meantime, N, S-CDs can cause yellow fluorescence quenching of riboflavin (VB2) with the detection limit of 0.121 μM under the concentration range from 1.000-20.000 μM. The possible mechanism is the functional groups at the surface of N, S-CDs combined with the hydroxyl, amino and carbonyl group of VB2 by protonation and hydrogen bonds. Further investigations for practical applications demonstrated that N, S-CDs has good prospects in Ga3+ananlysis and detection of VB2 in food. Moreover, N, S-CDs can be used to determine whether there is Ga3+ in transferrin, which can indirectly inhibit the growth of cancer cells through the influence on transporting iron ion. Therefore, it is profitable for preliminary diagnosis and treatment of cancer cells in the field of biomedicine.
期刊介绍:
The Microchemical Journal is a peer reviewed journal devoted to all aspects and phases of analytical chemistry and chemical analysis. The Microchemical Journal publishes articles which are at the forefront of modern analytical chemistry and cover innovations in the techniques to the finest possible limits. This includes fundamental aspects, instrumentation, new developments, innovative and novel methods and applications including environmental and clinical field.
Traditional classical analytical methods such as spectrophotometry and titrimetry as well as established instrumentation methods such as flame and graphite furnace atomic absorption spectrometry, gas chromatography, and modified glassy or carbon electrode electrochemical methods will be considered, provided they show significant improvements and novelty compared to the established methods.