Synthesis of C-glycosides enabled by palladium-catalyzed glycosylation reactions

IF 4.6 1区 化学 Q1 CHEMISTRY, ORGANIC Organic Chemistry Frontiers Pub Date : 2024-10-15 DOI:10.1039/D4QO01619J
Wenli Tong, Jie-Ping Wan and Jianchao Liu
{"title":"Synthesis of C-glycosides enabled by palladium-catalyzed glycosylation reactions","authors":"Wenli Tong, Jie-Ping Wan and Jianchao Liu","doi":"10.1039/D4QO01619J","DOIUrl":null,"url":null,"abstract":"<p >\r\n <em>C</em>-Glycosides are a privileged class of carbohydrates that exhibit remarkable biological and pharmaceutical activities. Transition metal-catalyzed cross-coupling reactions are powerful tools for the efficient and rapid construction of C–C bonds. Among various transition-metal catalyzed methods, palladium-catalyzed <em>C</em>-glycosylation is an effective and reliable approach to synthesize <em>C</em>-glycosides and involves the reaction of glycosyl donors and various reaction partners <em>via</em> C–C glycosidic bond formation under mild conditions with high regio/stereo-selectivities. In this review, palladium-catalyzed <em>C</em>-glycosylation reactions from 2020 to 2024 are summarized and discussed in detail, with focus on the synthesis of <em>C</em>-aryl glycosides, <em>C</em>-alkyl glycosides, <em>C</em>-alkenyl glycosides, and other functionalized <em>C</em>-glycosides. Some representative synthetic strategies and their transformation application along with reaction mechanisms are also highlighted.</p>","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":" 23","pages":" 6918-6941"},"PeriodicalIF":4.6000,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Chemistry Frontiers","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2024/qo/d4qo01619j","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0

Abstract

C-Glycosides are a privileged class of carbohydrates that exhibit remarkable biological and pharmaceutical activities. Transition metal-catalyzed cross-coupling reactions are powerful tools for the efficient and rapid construction of C–C bonds. Among various transition-metal catalyzed methods, palladium-catalyzed C-glycosylation is an effective and reliable approach to synthesize C-glycosides and involves the reaction of glycosyl donors and various reaction partners via C–C glycosidic bond formation under mild conditions with high regio/stereo-selectivities. In this review, palladium-catalyzed C-glycosylation reactions from 2020 to 2024 are summarized and discussed in detail, with focus on the synthesis of C-aryl glycosides, C-alkyl glycosides, C-alkenyl glycosides, and other functionalized C-glycosides. Some representative synthetic strategies and their transformation application along with reaction mechanisms are also highlighted.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
通过钯催化糖基化反应合成 C-糖苷
C-Glycosides 是一类特殊的碳水化合物,具有显著的生物和医药活性。过渡金属催化的交叉偶联反应是高效、快速构建 C-C 键的有力工具。在各种过渡金属催化方法中,钯催化的 C-糖基化是合成 C-糖苷的一种有效而可靠的方法,它涉及糖酰基供体和各种反应物在温和条件下通过 C-C 糖苷键的形成发生反应,具有很高的区域/立体选择性。本综述总结并详细讨论了 2020 年至 2024 年期间钯催化的 C-糖基化反应,重点是 C-芳基糖苷、C-烷基糖苷、C-烯基糖苷和其他功能化 C-糖苷的合成。此外,还重点介绍了一些具有代表性的合成策略及其转化应用以及反应机理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Organic Chemistry Frontiers
Organic Chemistry Frontiers CHEMISTRY, ORGANIC-
CiteScore
7.90
自引率
11.10%
发文量
686
审稿时长
1 months
期刊介绍: Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.
期刊最新文献
Copper-Catalyzed N-H Bond Chalcogenation of Anilines Synthesis, crystal growth, structure and photophysical properties of decafluoroanthracene and its co-crystals with polycyclic arenes Water-enabled α-C(sp3)–H amination via [1,6]-hydride transfer: green access to diazepino[6,5,4-cd]indoles Palladium-Catalyzed NHC Ligand-Controlled Regiodivergent Allyl-Fluoroallyl Cross-Couplings (BO)2-doped tetrathia[7]helicenes: synthesis and properties-change induced by “BO bonds inversion”
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1