Microbiome's role in musculoskeletal health through the gut-bone axis insights.

IF 12.2 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Gut Microbes Pub Date : 2024-10-10 DOI:10.1080/19490976.2024.2410478
Zhengrui Li,Qi Wang,Xufeng Huang,Yinteng Wu,Dan Shan
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Abstract

The interplay between the human microbiome and the musculoskeletal system represents a burgeoning field of research with profound implications for understanding and treating musculoskeletal disorders. This review articulates the pivotal role of the microbiome in modulating bone health, highlighting the gut-bone axis as a critical nexus for potential therapeutic intervention. Through a meticulous analysis of recent clinical research, we underscore the microbiome's influence on osteoporosis, sarcopenia, osteoarthritis, and rheumatoid arthritis, delineating both the direct and indirect mechanisms by which microbiota could impact musculoskeletal integrity and function. Our investigation reveals novel insights into the microbiota's contribution to bone density regulation, hormone production, immune modulation, and nutrient absorption, laying the groundwork for innovative microbiome-based strategies in musculoskeletal disease management. Significantly, we identify the challenges hindering the translation of research into clinical practice, including the limitations of current microbial sequencing techniques and the need for standardized methodologies in microbiome studies. Furthermore, we highlight promising directions for future research, particularly in the realm of personalized medicine, where the microbiome's variability offers unique opportunities for tailored treatment approaches. This review sets a new agenda for leveraging gut microbiota in the diagnosis, prevention, and treatment of musculoskeletal conditions, marking a pivotal step toward integrating microbiome science into clinical musculoskeletal care.
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通过肠道-骨骼轴洞察微生物组在肌肉骨骼健康中的作用。
人类微生物组与肌肉骨骼系统之间的相互作用是一个新兴的研究领域,对了解和治疗肌肉骨骼疾病有着深远的影响。本综述阐明了微生物组在调节骨骼健康方面的关键作用,强调肠道-骨骼轴是潜在治疗干预的关键纽带。通过对最新临床研究的细致分析,我们强调了微生物组对骨质疏松症、肌肉疏松症、骨关节炎和类风湿性关节炎的影响,并描述了微生物组影响肌肉骨骼完整性和功能的直接和间接机制。我们的研究揭示了微生物群对骨密度调节、激素分泌、免疫调节和营养吸收的新见解,为基于微生物群的肌肉骨骼疾病管理创新策略奠定了基础。值得注意的是,我们发现了阻碍研究成果转化为临床实践的挑战,包括当前微生物测序技术的局限性以及微生物组研究中标准化方法的必要性。此外,我们还强调了未来有希望的研究方向,特别是在个性化医疗领域,微生物组的可变性为量身定制的治疗方法提供了独特的机会。这篇综述为利用肠道微生物群诊断、预防和治疗肌肉骨骼疾病制定了新的议程,标志着将微生物组科学融入临床肌肉骨骼治疗迈出了关键的一步。
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来源期刊
Gut Microbes
Gut Microbes Medicine-Microbiology (medical)
CiteScore
18.20
自引率
3.30%
发文量
196
审稿时长
10 weeks
期刊介绍: The intestinal microbiota plays a crucial role in human physiology, influencing various aspects of health and disease such as nutrition, obesity, brain function, allergic responses, immunity, inflammatory bowel disease, irritable bowel syndrome, cancer development, cardiac disease, liver disease, and more. Gut Microbes serves as a platform for showcasing and discussing state-of-the-art research related to the microorganisms present in the intestine. The journal emphasizes mechanistic and cause-and-effect studies. Additionally, it has a counterpart, Gut Microbes Reports, which places a greater focus on emerging topics and comparative and incremental studies.
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