Harnessing the sensing and stimulation function of deep brain-machine interfaces: a new dawn for overcoming substance use disorders.

IF 5.8 1区医学 Q1 PSYCHIATRY Translational Psychiatry Pub Date : 2024-10-17 DOI:10.1038/s41398-024-03156-8

Danyang Chen, Zhixian Zhao, Jian Shi, Shengjie Li, Xinran Xu, Zhuojin Wu, Yingxin Tang, Na Liu, Wenhong Zhou, Changmao Ni, Bo Ma, Junya Wang, Jun Zhang, Li Huang, Zheng You, Ping Zhang, Zhouping Tang

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Abstract

Substance use disorders (SUDs) imposes profound physical, psychological, and socioeconomic burdens on individuals, families, communities, and society as a whole, but the available treatment options remain limited. Deep brain-machine interfaces (DBMIs) provide an innovative approach by facilitating efficient interactions between external devices and deep brain structures, thereby enabling the meticulous monitoring and precise modulation of neural activity in these regions. This pioneering paradigm holds significant promise for revolutionizing the treatment landscape of addictive disorders. In this review, we carefully examine the potential of closed-loop DBMIs for addressing SUDs, with a specific emphasis on three fundamental aspects: addictive behaviors-related biomarkers, neuromodulation techniques, and control policies. Although direct empirical evidence is still somewhat limited, rapid advancements in cutting-edge technologies such as electrophysiological and neurochemical recordings, deep brain stimulation, optogenetics, microfluidics, and control theory offer fertile ground for exploring the transformative potential of closed-loop DBMIs for ameliorating symptoms and enhancing the overall well-being of individuals struggling with SUDs.

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利用深度脑机接口的传感和刺激功能：克服药物使用障碍的新曙光。

药物使用失调症（SUD）给个人、家庭、社区和整个社会带来了深重的生理、心理和社会经济负担，但现有的治疗方案仍然有限。深部脑机接口（DBMI）通过促进外部设备与深部大脑结构之间的高效互动，从而实现对这些区域神经活动的细致监测和精确调节，提供了一种创新方法。这一开创性范例有望彻底改变成瘾性疾病的治疗现状。在这篇综述中，我们将仔细研究闭环 DBMIs 在治疗成瘾性疾病方面的潜力，重点关注三个基本方面：成瘾行为相关生物标记物、神经调控技术和控制策略。虽然直接的经验证据仍然有限，但是电生理和神经化学记录、深部脑刺激、光遗传学、微流控理论等前沿技术的快速发展为探索闭环 DBMI 在改善症状和提高与药物滥用作斗争的个体的整体福祉方面的变革潜力提供了肥沃的土壤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational Psychiatry PSYCHIATRY-

CiteScore

11.50

自引率

2.90%

发文量

484

审稿时长

23 weeks

期刊介绍： Psychiatry has suffered tremendously by the limited translational pipeline. Nobel laureate Julius Axelrod''s discovery in 1961 of monoamine reuptake by pre-synaptic neurons still forms the basis of contemporary antidepressant treatment. There is a grievous gap between the explosion of knowledge in neuroscience and conceptually novel treatments for our patients. Translational Psychiatry bridges this gap by fostering and highlighting the pathway from discovery to clinical applications, healthcare and global health. We view translation broadly as the full spectrum of work that marks the pathway from discovery to global health, inclusive. The steps of translation that are within the scope of Translational Psychiatry include (i) fundamental discovery, (ii) bench to bedside, (iii) bedside to clinical applications (clinical trials), (iv) translation to policy and health care guidelines, (v) assessment of health policy and usage, and (vi) global health. All areas of medical research, including — but not restricted to — molecular biology, genetics, pharmacology, imaging and epidemiology are welcome as they contribute to enhance the field of translational psychiatry.