{"title":"Programmable Artificial Skins Accomplish Antiscar Healing with Multiple Appendage Regeneration","authors":"Mingchen Xiong, Xinling Yang, Ziwei Shi, Jiangbing Xiang, Huanhuan Gao, Shuaifei Ji, Yingying Li, Wei Pi, Huating Chen, Hongliang Zhang, Mengyang Wang, Yan Li, Yiyue Hong, Dongsheng Liu, Xiaobing Fu, Yuanchen Dong, Xiaoyan Sun","doi":"10.1002/adma.202407322","DOIUrl":null,"url":null,"abstract":"Functional appendage regeneration is essential for skin rehabilitation, but it has always failed by current existing healing approaches, owing to their inefficacy in preventing disfiguring scars. In this study, a novel regeneration-directing artificial skin (RDAS) system is presented, which is based on the rational design of multi-layered hydrogels that closely mimic natural skin matrices. By leveraging the programmability and architectural rigidity of DNA components, without the need for exogenous cell transplantation, such RDAS effectively minimizes tissue fibrosis by accurately guiding the regenerative process in wound fibroblasts, enabling rapid scarless wound repair, restoration of dermal function, and successful in situ regeneration of multiple appendages, such as hair follicles (HFs), sebaceous glands (SGs), and sweat glands (SwGs). Therefore, the RDAS offers a cell-free antiscarring therapeutic strategy for regenerative wound healing, resulting in improved outcomes. This innovative approach holds great potential for future clinical applications and burn rehabilitation.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":null,"pages":null},"PeriodicalIF":27.4000,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Materials","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1002/adma.202407322","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Functional appendage regeneration is essential for skin rehabilitation, but it has always failed by current existing healing approaches, owing to their inefficacy in preventing disfiguring scars. In this study, a novel regeneration-directing artificial skin (RDAS) system is presented, which is based on the rational design of multi-layered hydrogels that closely mimic natural skin matrices. By leveraging the programmability and architectural rigidity of DNA components, without the need for exogenous cell transplantation, such RDAS effectively minimizes tissue fibrosis by accurately guiding the regenerative process in wound fibroblasts, enabling rapid scarless wound repair, restoration of dermal function, and successful in situ regeneration of multiple appendages, such as hair follicles (HFs), sebaceous glands (SGs), and sweat glands (SwGs). Therefore, the RDAS offers a cell-free antiscarring therapeutic strategy for regenerative wound healing, resulting in improved outcomes. This innovative approach holds great potential for future clinical applications and burn rehabilitation.
功能性附属器官再生对皮肤康复至关重要,但由于现有的治疗方法在防止毁容性疤痕方面效果不佳,因此一直未能奏效。本研究介绍了一种新型再生引导人造皮肤(RDAS)系统,它基于多层水凝胶的合理设计,可近似模拟天然皮肤基质。该系统利用 DNA 成分的可编程性和结构刚性,无需外源细胞移植,通过精确引导伤口成纤维细胞的再生过程,有效减少组织纤维化,实现快速无痕伤口修复,恢复真皮功能,并成功实现毛囊(HF)、皮脂腺(SG)和汗腺(SwG)等多种附属器官的原位再生。因此,RDAS 为伤口再生愈合提供了一种无细胞抗瘢痕治疗策略,从而改善了疗效。这种创新方法在未来的临床应用和烧伤康复方面具有巨大潜力。
期刊介绍:
Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.