Advances and Functional Integration of Hydrogel Composites as Drug Delivery Systems in Contemporary Dentistry.

IF 5 3区 化学 Q1 POLYMER SCIENCE Gels Pub Date : 2024-10-16 DOI:10.3390/gels10100661
Dragos Nicolae Fratila, Dragos Ioan Virvescu, Ionut Luchian, Monica Hancianu, Elena Raluca Baciu, Oana Butnaru, Dana Gabriela Budala
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Abstract

This study explores the recent advances of and functional insights into hydrogel composites, materials that have gained significant attention for their versatile applications across various fields, including contemporary dentistry. Hydrogels, known for their high water content and biocompatibility, are inherently soft but often limited by mechanical fragility. Key areas of focus include the customization of hydrogel composites for biomedical applications, such as drug delivery systems, wound dressings, and tissue engineering scaffolds, where improved mechanical properties and bioactivity are critical. In dentistry, hydrogels are utilized for drug delivery systems targeting oral diseases, dental adhesives, and periodontal therapies due to their ability to adhere to the mucosa, provide localized treatment, and support tissue regeneration. Their unique properties, such as mucoadhesion, controlled drug release, and stimuli responsiveness, make them ideal candidates for treating oral conditions. This review highlights both experimental breakthroughs and theoretical insights into the structure-property relationships within hydrogel composites, aiming to guide future developments in the design and application of these multifunctional materials in dentistry. Ultimately, hydrogel composites represent a promising frontier for advancing materials science with far-reaching implications in healthcare, environmental technology, and beyond.

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水凝胶复合材料作为药物输送系统在当代牙科领域的发展和功能整合。
本研究探讨了水凝胶复合材料的最新进展和功能见解,这种材料因其在包括当代牙科在内的各个领域的广泛应用而备受关注。水凝胶因其高含水量和生物相容性而闻名,本身柔软,但往往受到机械脆性的限制。重点领域包括为生物医学应用定制水凝胶复合材料,如药物输送系统、伤口敷料和组织工程支架,在这些应用中,改善机械性能和生物活性至关重要。在牙科领域,水凝胶可用于针对口腔疾病的给药系统、牙科粘合剂和牙周治疗,因为它们能够粘附在粘膜上,提供局部治疗并支持组织再生。它们具有独特的特性,如粘液粘附性、药物释放可控性和刺激响应性,是治疗口腔疾病的理想选择。本综述重点介绍了水凝胶复合材料结构-性能关系方面的实验突破和理论见解,旨在指导牙科领域设计和应用这些多功能材料的未来发展。归根结底,水凝胶复合材料是材料科学发展的一个前景广阔的前沿领域,对医疗保健、环保技术等领域有着深远的影响。
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来源期刊
Gels
Gels POLYMER SCIENCE-
CiteScore
4.70
自引率
19.60%
发文量
707
审稿时长
11 weeks
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