Eco-Friendly Microwave Synthesis of Sodium Alginate-Chitosan Hydrogels for Effective Curcumin Delivery and Controlled Release.

IF 5 3区 化学 Q1 POLYMER SCIENCE Gels Pub Date : 2024-10-02 DOI:10.3390/gels10100637
Ivan Ristić, Ljubiša Nikolić, Suzana Cakić, Vesna Nikolić, Jelena Tanasić, Jelena Zvezdanović, Marija Krstić
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Abstract

In this study, we developed sodium alginate-chitosan hydrogels using a microwave-assisted synthesis method, aligning with green chemistry principles for enhanced sustainability. This eco-friendly approach minimizes chemical use and waste while boosting efficiency. A curcumin:2-hydroxypropyl-β-cyclodextrin complex was incorporated into the hydrogels, significantly increasing the solubility and bioavailability of curcumin. Fourier Transform Infrared Spectroscopy (FTIR) analysis confirmed the structure and successful incorporation of curcumin, in both its pure and complexed forms, into the polymer matrix. Differential scanning calorimetry revealed distinct thermal transitions influenced by the hydrogel composition and physical cross-linking. Hydrogels with higher alginate content had higher swelling ratios (338%), while those with more chitosan showed the lowest swelling ratios (254%). Scanning Electron Microscopy (SEM) micrographs showed a porous structure as well as successful incorporation of curcumin or its complex. Curcumin release studies indicated varying releasing rates between its pure and complexed forms. The chitosan-dominant hydrogel exhibited the slowest release rate of pure curcumin, while the alginate-dominant hydrogel exhibited the fastest. Conversely, for curcumin from the inclusion complex, a higher chitosan proportion led to the fastest release rate, while a higher alginate proportion resulted in the slowest. This study demonstrates that the form of curcumin incorporation and gel matrix composition critically influence the release profile. Our findings offer valuable insights for designing effective curcumin delivery systems, representing a significant advancement in biodegradable and sustainable drug delivery technologies.

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微波合成海藻酸钠-壳聚糖水凝胶,用于有效输送和控释姜黄素的环保型方法
在本研究中,我们采用微波辅助合成法开发了海藻酸钠-壳聚糖水凝胶,该方法符合绿色化学原则,可提高可持续性。这种生态友好型方法最大程度地减少了化学品的使用和浪费,同时提高了效率。水凝胶中加入了姜黄素:2-羟丙基-β-环糊精复合物,显著提高了姜黄素的溶解度和生物利用率。傅立叶变换红外光谱(FTIR)分析证实了姜黄素的结构,并成功地将纯姜黄素和络合姜黄素融入聚合物基质中。差示扫描量热法揭示了受水凝胶成分和物理交联影响的不同热转变。海藻酸含量较高的水凝胶具有较高的膨胀率(338%),而壳聚糖含量较高的水凝胶膨胀率最低(254%)。扫描电子显微镜(SEM)显微照片显示了多孔结构以及姜黄素或其复合物的成功加入。姜黄素释放研究表明,纯姜黄素和姜黄素复合物的释放率各不相同。以壳聚糖为主的水凝胶释放纯姜黄素的速度最慢,而以海藻酸为主的水凝胶释放速度最快。相反,对于包合物中的姜黄素,壳聚糖比例越高,释放速度越快,而海藻酸比例越高,释放速度越慢。这项研究表明,姜黄素的掺入形式和凝胶基质成分对释放曲线有着至关重要的影响。我们的研究结果为设计有效的姜黄素给药系统提供了宝贵的见解,是生物可降解和可持续给药技术的一大进步。
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来源期刊
Gels
Gels POLYMER SCIENCE-
CiteScore
4.70
自引率
19.60%
发文量
707
审稿时长
11 weeks
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