Prenatal metal exposures and kidney function in adolescence in Project Viva.

IF 5.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Environmental Health Pub Date : 2024-10-30 DOI:10.1186/s12940-024-01135-6

Natalie F Price, Pi-I D Lin, Andres Cardenas, Sheryl L Rifas-Shiman, Ami R Zota, Marie-France Hivert, Emily Oken, Izzuddin M Aris, Alison P Sanders

{"title":"Prenatal metal exposures and kidney function in adolescence in Project Viva.","authors":"Natalie F Price, Pi-I D Lin, Andres Cardenas, Sheryl L Rifas-Shiman, Ami R Zota, Marie-France Hivert, Emily Oken, Izzuddin M Aris, Alison P Sanders","doi":"10.1186/s12940-024-01135-6","DOIUrl":null,"url":null,"abstract":"Background: The developing kidney is vulnerable to prenatal environmental factors such as metal exposure, potentially altering the risk of later-life kidney dysfunction. This study examines the relationship between prenatal metal exposures, individually and as mixtures, and adolescent kidney function in Project Viva, a prospective longitudinal birth cohort in Massachusetts, USA.Methods: We used data on metals measured in blood during pregnancy including 15 in the first trimester and four in the second trimester. We calculated estimated glomerular filtration rate (eGFR) in adolescents (mean: 17.7 years) using cystatin C- (eGFRcys) and creatinine-based (eGFRcreat) equations for children. We used linear regression for single metal analyses, and Bayesian kernel machine regression and quantile-based g-computation for mixture analyses, adjusting for relevant covariates. To account for multiple comparisons in the single metal analyses, we applied the Holm-Bonferroni procedure to control the false discovery rate.Results: This study included 371 participants with first trimester metals and adolescent eGFR, and 256 with second trimester metals. Each doubling in first trimester cadmium concentration was associated with lower adolescent eGFRcys (β:-1.51; 95% CI:-2.83, -0.18). Each doubling in first trimester chromium (β:-1.45; 95% CI:-2.71, -0.19), nickel (β:-1.91; 95% CI:-3.65, -0.16), and vanadium (β:-1.69; 95% CI:-3.21, -0.17) was associated with lower adolescent eGFRcreat. After adjusting for multiple comparisons, p-values for associations between adolescent eGFR and chromium, nickel, vanadium and cadmium did not meet the criteria for significance. Metal mixture analyses did not identify statistically significant associations with adolescent eGFR.Conclusions: These findings have important implications for future studies investigating the potential mechanisms through which prenatal metal exposures affect long-term kidney health in children.","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":null,"pages":null},"PeriodicalIF":5.3000,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526622/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environmental Health","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1186/s12940-024-01135-6","RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The developing kidney is vulnerable to prenatal environmental factors such as metal exposure, potentially altering the risk of later-life kidney dysfunction. This study examines the relationship between prenatal metal exposures, individually and as mixtures, and adolescent kidney function in Project Viva, a prospective longitudinal birth cohort in Massachusetts, USA.

Methods: We used data on metals measured in blood during pregnancy including 15 in the first trimester and four in the second trimester. We calculated estimated glomerular filtration rate (eGFR) in adolescents (mean: 17.7 years) using cystatin C- (eGFRcys) and creatinine-based (eGFRcreat) equations for children. We used linear regression for single metal analyses, and Bayesian kernel machine regression and quantile-based g-computation for mixture analyses, adjusting for relevant covariates. To account for multiple comparisons in the single metal analyses, we applied the Holm-Bonferroni procedure to control the false discovery rate.

Results: This study included 371 participants with first trimester metals and adolescent eGFR, and 256 with second trimester metals. Each doubling in first trimester cadmium concentration was associated with lower adolescent eGFRcys (β:-1.51; 95% CI:-2.83, -0.18). Each doubling in first trimester chromium (β:-1.45; 95% CI:-2.71, -0.19), nickel (β:-1.91; 95% CI:-3.65, -0.16), and vanadium (β:-1.69; 95% CI:-3.21, -0.17) was associated with lower adolescent eGFRcreat. After adjusting for multiple comparisons, p-values for associations between adolescent eGFR and chromium, nickel, vanadium and cadmium did not meet the criteria for significance. Metal mixture analyses did not identify statistically significant associations with adolescent eGFR.

Conclusions: These findings have important implications for future studies investigating the potential mechanisms through which prenatal metal exposures affect long-term kidney health in children.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

万岁项目中的产前金属暴露与青春期肾功能。

背景：发育中的肾脏很容易受到产前环境因素（如金属暴露）的影响，从而可能改变日后出现肾功能障碍的风险。本研究在美国马萨诸塞州的前瞻性纵向出生队列 "Project Viva "中研究了产前单独或混合物金属暴露与青少年肾功能之间的关系：我们使用了孕期血液中测量到的金属数据，包括孕期前三个月的 15 种金属和孕期后三个月的 4 种金属。我们使用胱抑素 C（eGFRcys）和基于肌酐的儿童（eGFRcreat）方程计算了青少年（平均：17.7 岁）的估计肾小球滤过率（eGFR）。我们使用线性回归进行单一金属分析，使用贝叶斯核机器回归和基于量子的 g 计算进行混合分析，并对相关协变量进行调整。为了在单一金属分析中考虑多重比较，我们采用了 Holm-Bonferroni 程序来控制误发现率：本研究共纳入了 371 名妊娠前三个月金属和青少年 eGFR 参与者，以及 256 名妊娠后三个月金属参与者。怀孕前三个月镉浓度每增加一倍，青少年 eGFRcys 就会降低（β：-1.51；95% CI：-2.83，-0.18）。前三个月铬浓度每增加一倍（β：-1.45；95% CI：-2.71，-0.19）、镍浓度每增加一倍（β：-1.91；95% CI：-3.65，-0.16）和钒浓度每增加一倍（β：-1.69；95% CI：-3.21，-0.17），青少年的 eGFRcreat 就会降低。经多重比较调整后，青少年 eGFR 与铬、镍、钒和镉之间的相关性 p 值未达到显著性标准。金属混合物分析未发现与青少年 eGFR 有统计学意义的关联：这些发现对今后研究产前金属暴露影响儿童长期肾脏健康的潜在机制具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Environmental Health 环境科学-公共卫生、环境卫生与职业卫生

CiteScore

10.10

自引率

1.70%

发文量

115

审稿时长

3.0 months

期刊介绍： Environmental Health publishes manuscripts on all aspects of environmental and occupational medicine and related studies in toxicology and epidemiology. Environmental Health is aimed at scientists and practitioners in all areas of environmental science where human health and well-being are involved, either directly or indirectly. Environmental Health is a public health journal serving the public health community and scientists working on matters of public health interest and importance pertaining to the environment.