Unlocking the regenerative key: Targeting stem cell factors for bone renewal.

IF 6.7 1区 工程技术 Q1 CELL & TISSUE ENGINEERING Journal of Tissue Engineering Pub Date : 2024-10-27 eCollection Date: 2024-01-01 DOI:10.1177/20417314241287491
Gul Karima, Hwan D Kim
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Abstract

Stem cell factors (SCFs) are pivotal factors existing in both soluble and membrane-bound forms, expressed by endothelial cells (ECs) and fibroblasts throughout the body. These factors enhance cell growth, viability, and migration in multipotent cell lineages. The preferential expression of SCF by arteriolar ECs indicates that arterioles create a unique microenvironment tailored to hematopoietic stem cells (HSCs). Insufficiency of SCF within bone marrow (BM)-derived adipose tissue results in decreased their overall cellularity, affecting HSCs and their immediate progenitors critical for generating diverse blood cells and maintaining the hematopoietic microenvironment. SCF deficiency disrupts BM function, impacting the production and differentiation of HSCs. Additionally, deleting SCF from adipocytes reduces lipogenesis, highlighting the crucial role of SCF/c-kit signaling in controlling lipid accumulation. This review elucidates the sources, roles, mechanisms, and molecular strategies of SCF in bone renewal, offering a comprehensive overview of recent advancements, challenges, and future directions for leveraging SCF as a key agent in regenerative medicine.

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打开再生之钥:锁定干细胞因子,促进骨骼再生
干细胞因子(SCFs)是以可溶性和膜结合形式存在的关键因子,由全身的内皮细胞(ECs)和成纤维细胞表达。这些因子可促进多能细胞系的细胞生长、活力和迁移。动脉内皮细胞优先表达SCF表明,动脉为造血干细胞(HSCs)创造了一个独特的微环境。骨髓(BM)衍生脂肪组织中的SCF不足会导致其整体细胞性降低,影响造血干细胞及其对生成多样化血细胞和维持造血微环境至关重要的直接祖细胞。SCF 缺乏会破坏 BM 功能,影响造血干细胞的生成和分化。此外,从脂肪细胞中删除 SCF 会减少脂肪的生成,这凸显了 SCF/c-kit 信号在控制脂质积累中的关键作用。这篇综述阐明了 SCF 在骨更新中的来源、作用、机制和分子策略,全面概述了利用 SCF 作为再生医学关键药物的最新进展、挑战和未来方向。
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来源期刊
Journal of Tissue Engineering
Journal of Tissue Engineering Engineering-Biomedical Engineering
CiteScore
11.60
自引率
4.90%
发文量
52
审稿时长
12 weeks
期刊介绍: The Journal of Tissue Engineering (JTE) is a peer-reviewed, open-access journal dedicated to scientific research in the field of tissue engineering and its clinical applications. Our journal encompasses a wide range of interests, from the fundamental aspects of stem cells and progenitor cells, including their expansion to viable numbers, to an in-depth understanding of their differentiation processes. Join us in exploring the latest advancements in tissue engineering and its clinical translation.
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