Copper homeostasis and copper-induced cell death in tumor immunity: implications for therapeutic strategies in cancer immunotherapy.

IF 9.5 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Biomarker Research Pub Date : 2024-10-31 DOI:10.1186/s40364-024-00677-8
Suhang Zhang, Qibo Huang, Tuo Ji, Qilin Li, Chuanyu Hu
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Abstract

Copper is an important trace element for maintaining key biological functions such as cellular respiration, nerve conduction, and antioxidant defense. Maintaining copper homeostasis is critical for human health, and its imbalance has been linked to various diseases, especially cancer. Cuproptosis, a novel mechanism of copper-induced cell death, provides new therapeutic opportunities for metal ion regulation to interact with cell fate. This review provides insights into the complex mechanisms of copper metabolism, the molecular basis of cuproptosis, and its association with cancer development. We assess the role of cuproptosis-related genes (CRGs) associated with tumorigenesis, their importance as prognostic indicators and therapeutic targets, and the impact of copper homeostasis on the tumor microenvironment (TME) and immune response. Ultimately, this review highlights the complex interplay between copper, cuproptosis, and cancer immunotherapy.

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肿瘤免疫中的铜平衡和铜诱导的细胞死亡:对癌症免疫疗法中治疗策略的影响。
铜是维持细胞呼吸、神经传导和抗氧化防御等关键生物功能的重要微量元素。维持铜的平衡对人体健康至关重要,而铜的失衡与各种疾病,尤其是癌症有关。铜中毒是铜诱导细胞死亡的一种新机制,它为金属离子调控与细胞命运的相互作用提供了新的治疗机会。本综述深入探讨了铜代谢的复杂机制、铜中毒的分子基础及其与癌症发展的关联。我们评估了与肿瘤发生相关的铜氧化相关基因(CRGs)的作用、它们作为预后指标和治疗靶点的重要性,以及铜平衡对肿瘤微环境(TME)和免疫反应的影响。最后,这篇综述强调了铜、铜突变和癌症免疫疗法之间复杂的相互作用。
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来源期刊
Biomarker Research
Biomarker Research Biochemistry, Genetics and Molecular Biology-Molecular Medicine
CiteScore
15.80
自引率
1.80%
发文量
80
审稿时长
10 weeks
期刊介绍: Biomarker Research, an open-access, peer-reviewed journal, covers all aspects of biomarker investigation. It seeks to publish original discoveries, novel concepts, commentaries, and reviews across various biomedical disciplines. The field of biomarker research has progressed significantly with the rise of personalized medicine and individual health. Biomarkers play a crucial role in drug discovery and development, as well as in disease diagnosis, treatment, prognosis, and prevention, particularly in the genome era.
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