Pub Date : 2026-02-09DOI: 10.1186/s40364-026-00903-5
Zhiying Liu, Yi Wu, Peiqi Xu, Huaxi Xu, Kai Yin, Shengjun Wang
{"title":"Semaphorins: from CD8⁺ T cells to cancer immunotherapy.","authors":"Zhiying Liu, Yi Wu, Peiqi Xu, Huaxi Xu, Kai Yin, Shengjun Wang","doi":"10.1186/s40364-026-00903-5","DOIUrl":"https://doi.org/10.1186/s40364-026-00903-5","url":null,"abstract":"","PeriodicalId":54225,"journal":{"name":"Biomarker Research","volume":" ","pages":""},"PeriodicalIF":11.5,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-06DOI: 10.1186/s40364-026-00894-3
Alvaro Monago-Sánchez, Laura Mateos-Madrigal, Josefa Carrión-Navarro, Ana Hernández-Martínez, Carlos Martínez-Riveiro, María Castelló-Pons, María Victoria Pacheco-Fuenmayor, Raquel Gutiérrez-González, Noemí Lomillos-Prieto, Ricardo Prat-Acín, Santiago Gil-Robles Mathieu, Cristina Aracil-González, Angel Pérez-Núñez, Francisco Pérez-Rodríguez, Pilar Sánchez-Gómez, Beatriz Martín-Jouve, Antonio J Sánchez-López, Noemi García-Romero, Ángel Ayuso-Sacido
{"title":"Precision oncology in a dish: patient-derived glioma organoids to guide novel therapeutic strategies.","authors":"Alvaro Monago-Sánchez, Laura Mateos-Madrigal, Josefa Carrión-Navarro, Ana Hernández-Martínez, Carlos Martínez-Riveiro, María Castelló-Pons, María Victoria Pacheco-Fuenmayor, Raquel Gutiérrez-González, Noemí Lomillos-Prieto, Ricardo Prat-Acín, Santiago Gil-Robles Mathieu, Cristina Aracil-González, Angel Pérez-Núñez, Francisco Pérez-Rodríguez, Pilar Sánchez-Gómez, Beatriz Martín-Jouve, Antonio J Sánchez-López, Noemi García-Romero, Ángel Ayuso-Sacido","doi":"10.1186/s40364-026-00894-3","DOIUrl":"https://doi.org/10.1186/s40364-026-00894-3","url":null,"abstract":"","PeriodicalId":54225,"journal":{"name":"Biomarker Research","volume":" ","pages":""},"PeriodicalIF":11.5,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-30DOI: 10.1186/s40364-025-00886-9
Asal Ziaei, MohammadBagher Kargar, Zeinab Shirvani-Farsani, Mahdieh MehrabMohseni
Neurodegenerative disorders involve the gradual breakdown of neurons, leading to problems with thinking, movement, and mental health. More evidence is emerging about the important roles of non-coding RNAs (ncRNAs). CircRNAs are a type of ncRNA formed through back-splicing and are widely present in the mammalian brain. They play crucial roles in brain development and mainly regulate gene expression and post-transcriptional processes by acting as molecular sponges for miRNAs and RBPs. eRNAs are another class of ncRNAs. They are produced from enhancer regions of the genome and act as vital regulatory elements in gene expression. There is increasing evidence that abnormal levels of circRNAs and eRNAs can be found in many human diseases, including neurodegenerative conditions. This suggests they could have important clinical uses in these illnesses. The unique stability and disease-specific expression patterns of circRNAs and eRNAs in biofluids like blood and cerebrospinal fluid make them strong candidates for noninvasive biomarkers in neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and multiple sclerosis. Additionally, their roles in crucial pathological pathways open new opportunities for treatment. This includes strategies that target RNA, such as antisense oligonucleotides or miRNA sponges, to influence gene expression networks. This review gathers recent findings to propose that circRNAs and eRNAs might introduce a new layer of regulation in neurodegeneration, providing exciting possibilities for real-world applications.
{"title":"Emerging roles of circular RNAs and enhancer RNAs: new insights into the development and management of neurodegenerative disorders.","authors":"Asal Ziaei, MohammadBagher Kargar, Zeinab Shirvani-Farsani, Mahdieh MehrabMohseni","doi":"10.1186/s40364-025-00886-9","DOIUrl":"https://doi.org/10.1186/s40364-025-00886-9","url":null,"abstract":"<p><p>Neurodegenerative disorders involve the gradual breakdown of neurons, leading to problems with thinking, movement, and mental health. More evidence is emerging about the important roles of non-coding RNAs (ncRNAs). CircRNAs are a type of ncRNA formed through back-splicing and are widely present in the mammalian brain. They play crucial roles in brain development and mainly regulate gene expression and post-transcriptional processes by acting as molecular sponges for miRNAs and RBPs. eRNAs are another class of ncRNAs. They are produced from enhancer regions of the genome and act as vital regulatory elements in gene expression. There is increasing evidence that abnormal levels of circRNAs and eRNAs can be found in many human diseases, including neurodegenerative conditions. This suggests they could have important clinical uses in these illnesses. The unique stability and disease-specific expression patterns of circRNAs and eRNAs in biofluids like blood and cerebrospinal fluid make them strong candidates for noninvasive biomarkers in neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and multiple sclerosis. Additionally, their roles in crucial pathological pathways open new opportunities for treatment. This includes strategies that target RNA, such as antisense oligonucleotides or miRNA sponges, to influence gene expression networks. This review gathers recent findings to propose that circRNAs and eRNAs might introduce a new layer of regulation in neurodegeneration, providing exciting possibilities for real-world applications.</p>","PeriodicalId":54225,"journal":{"name":"Biomarker Research","volume":" ","pages":""},"PeriodicalIF":11.5,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-27DOI: 10.1186/s40364-026-00899-y
Yang Gao, Jianlin Hu, Ning An, Xinyu Wen, Chunrui Li
{"title":"In vivo engineering of CAR-T cells: delivery strategies and clinical translation.","authors":"Yang Gao, Jianlin Hu, Ning An, Xinyu Wen, Chunrui Li","doi":"10.1186/s40364-026-00899-y","DOIUrl":"10.1186/s40364-026-00899-y","url":null,"abstract":"","PeriodicalId":54225,"journal":{"name":"Biomarker Research","volume":" ","pages":"23"},"PeriodicalIF":11.5,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12857126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146068614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of Epstein-Barr virus DNA methylation and load in saliva in the management of individuals at high risk of nasopharyngeal carcinoma.","authors":"Xiao-Hui Zheng, Ting Zhou, Xi-Zhao Li, Xiao-Jing Yang, Yu-Meng Zhang, Cao-Li Tang, Cheng-Tao Jiang, Pei-Fen Zhang, Ying Liao, Yong-Qiao He, Wen-Qiong Xue, Tong-Min Wang, Weimin Ye, Wei-Hua Jia","doi":"10.1186/s40364-026-00897-0","DOIUrl":"10.1186/s40364-026-00897-0","url":null,"abstract":"","PeriodicalId":54225,"journal":{"name":"Biomarker Research","volume":"14 1","pages":"17"},"PeriodicalIF":11.5,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12828917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146031682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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