Exposure to and Transplacental Transfer of Per- and Polyfluoroalkyl Substances in a Twin Pregnancy Cohort in Korea.

IF 10.8 1区 环境科学与生态学 Q1 ENGINEERING, ENVIRONMENTAL 环境科学与技术 Pub Date : 2024-11-06 DOI:10.1021/acs.est.4c04915
Na-Youn Park, Sun Wook Cho, Ye Eun Seo, Heeyeon Chae, Inae Lee, Young Ah Lee, Jong Kwan Jun, Eun Na Kim, Jeong-Won Oh, Kyungho Choi, Younglim Kho
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Abstract

Twin pregnancies involving assisted reproductive technology, particularly among older women, are considered to be high risk and vulnerable to chemical exposures. Per- and polyfluoroalkyl substances (PFAS) can cross the placenta and affect the fetus, but their transplacental transfer (TPT) is not well characterized for twin pregnancies. We employed a subset of twin pregnancies from the Ideal Breast Milk (IBM) cohort and measured the levels of PFAS and related chemicals in maternal (n = 78) and cord serum (n = 156) samples. L-PFOS and PFOA were detected at higher levels in maternal serum, with geometric means of 4.22 and 2.80 ng/mL, respectively, while the level of Br-PFHxS was higher in cord serum (0.29 ng/mL). Higher maternal PFAS levels were associated with the occurrence of maternal vascular malperfusion. Greater differences in cord PFAS levels between twin newborns were associated with higher maternal PFAS levels and an asymmetrical placental perfusion. The TPT ratio exhibited a U-shaped pattern with the number of carbons of PFAS, similar to a singleton pregnancy. Moreover, those with eight carbon atoms, i.e., 9Cl-PF3ONS, PFOA, and PFOS, showed different TPT efficiencies with respect to their structure and functional group. While the twin pregnancy does not appear to influence exposure levels or TPT efficiencies of PFAS and related chemicals, the consequences of the exposure warrant further investigations in this population.

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韩国双胎妊娠队列中的全氟和多氟烷基物质暴露和经胎盘转移。
涉及辅助生殖技术的双胎妊娠,尤其是高龄产妇的双胎妊娠,被认为是高风险和易受化学品暴露影响的妊娠。全氟烷基和多氟烷基物质(PFAS)可穿过胎盘影响胎儿,但双胎妊娠经胎盘转移(TPT)的特点并不明显。我们采用了理想母乳(IBM)队列中的双胎妊娠子集,测量了母体(78 例)和脐带血清(156 例)样本中 PFAS 和相关化学物质的水平。在母体血清中检测到的 L-PFOS 和 PFOA 含量较高,几何平均数分别为 4.22 和 2.80 纳克/毫升,而在脐带血清中检测到的 Br-PFHxS 含量较高(0.29 纳克/毫升)。母体PFAS水平较高与母体血管灌注不良的发生有关。双胎新生儿之间脐带 PFAS 水平的较大差异与母体 PFAS 水平较高和胎盘灌注不对称有关。随着 PFAS 碳原子数的增加,TPT 比值呈 U 型,与单胎妊娠相似。此外,具有八个碳原子的全氟辛烷磺酸(即 9Cl-PF3ONS、PFOA 和 PFOS)因其结构和官能团的不同而表现出不同的 TPT 效应。虽然双胎妊娠似乎不会影响 PFAS 及相关化学物质的暴露水平或 TPT 去除率,但这一人群的暴露后果值得进一步研究。
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来源期刊
环境科学与技术
环境科学与技术 环境科学-工程:环境
CiteScore
17.50
自引率
9.60%
发文量
12359
审稿时长
2.8 months
期刊介绍: Environmental Science & Technology (ES&T) is a co-sponsored academic and technical magazine by the Hubei Provincial Environmental Protection Bureau and the Hubei Provincial Academy of Environmental Sciences. Environmental Science & Technology (ES&T) holds the status of Chinese core journals, scientific papers source journals of China, Chinese Science Citation Database source journals, and Chinese Academic Journal Comprehensive Evaluation Database source journals. This publication focuses on the academic field of environmental protection, featuring articles related to environmental protection and technical advancements.
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