Synthesis, Biological Evaluation, and Computational Study of Novel 1,2,3‐Triazole‐Tethered Chalcone Derivatives

IF 0.8 4区 化学 Q4 CHEMISTRY, ORGANIC Russian Journal of Organic Chemistry Pub Date : 2024-11-07 DOI:10.1134/S1070428024090161
R. A. Kawale, M. H. Shaikh, H. N. Akolkar, V. M. Khedkar, D. N. Raut, S. N. Shelke
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Abstract

In search of novel anti-inflammatory and antioxidant agents with improved potency, a small focused library of 1,2,3-triazole-based chalcone derivatives has been efficiently prepared via the click chemistry approach. All synthesized compounds’ Structures were characterized with the help of IR, 1H NMR, 13C NMR, and mass spectroscopic techniques. All the synthesized novel derivatives were evaluated for their anti-inflammatory activity. Molecular docking studies against COX-2 gave valuable insights into the mechanistic basis of the demonstrated anti-inflammatory activity. Further, the synthesized compounds were found to have potential antioxidant activity.

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新型 1,2,3-三唑系链查耳酮衍生物的合成、生物学评价和计算研究
为了寻找具有更好药效的新型抗炎和抗氧化剂,我们通过点击化学方法高效地制备了一个小型的 1,2,3-三唑基查耳酮衍生物库。利用红外光谱、1H NMR、13C NMR 和质谱技术对所有合成化合物的结构进行了表征。对所有合成的新型衍生物进行了抗炎活性评估。针对 COX-2 的分子对接研究为了解所展示的抗炎活性的机理基础提供了宝贵的见解。此外,还发现合成的化合物具有潜在的抗氧化活性。
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来源期刊
CiteScore
1.40
自引率
25.00%
发文量
139
审稿时长
3-6 weeks
期刊介绍: Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.
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