{"title":"Efficient Synthesis of 8-Fluoro-10-methyl-3,4-dihydrobenzo[b][1,6]naphthyridine-2(1H)-carboxamides and Their Cytotoxic Activity","authors":"R. K. Rao, M. Surana, S. Kankala","doi":"10.1134/S1070428024090203","DOIUrl":null,"url":null,"abstract":"<p>A facile synthesis of a new series of 8-fluoro-10-methyl-3,4-dihydrobenzo[<i>b</i>][1,6]naphthyridine-2(1<i>H</i>)-carboxamide hybrids in high yields has been developed via coupling reaction. The synthesized compounds were evaluated for their in vitro anticancer activity against a panel of four human tumor cell lines, viz., MCF-7 (breast cancer), A-549 (lung cancer), OVACR-3 (ovarian cancer) and HeLa (cervical cancer). Compounds <b>12a</b>, <b>12c</b>, <b>12e</b>, <b>12h</b>, and <b>12l</b> demonstrated higher activity than that of cisplatin taken as positive control.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070428024090203","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
A facile synthesis of a new series of 8-fluoro-10-methyl-3,4-dihydrobenzo[b][1,6]naphthyridine-2(1H)-carboxamide hybrids in high yields has been developed via coupling reaction. The synthesized compounds were evaluated for their in vitro anticancer activity against a panel of four human tumor cell lines, viz., MCF-7 (breast cancer), A-549 (lung cancer), OVACR-3 (ovarian cancer) and HeLa (cervical cancer). Compounds 12a, 12c, 12e, 12h, and 12l demonstrated higher activity than that of cisplatin taken as positive control.
期刊介绍：
Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.
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