Y. Zhang, Y. Deng, X. Lan, Y. Lu, D. Zhao, W. Wang, L. Chen, Z. Yan
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引用次数: 0
Abstract
In order to obtain amide compounds with enhanced antifungal activity, twelve 2-aminothiazole derivatives were synthesized using combinatorial chemistry techniques. The newly synthesized compounds were characterized by using various techniques such as 1H NMR, 13C NMR, ESI-MS, and elemental analysis. Notably, compound 11b not only exhibited a high inhibitory rate against Sclerotinia sclerotiorum but also possessed certain anticancer effects. Molecular docking analysis provided a scientific basis for how this compound achieves its antifungal effects.
期刊介绍：
Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.
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