Design of Remote-Controllable Diels–Alder Platform on Magnetic Nanoparticles via Layer-by-Layer Assembly for AC Magnetic Field-Triggered Drug Release

IF 3.7 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Langmuir Pub Date : 2024-11-02 DOI:10.1021/acs.langmuir.4c0299810.1021/acs.langmuir.4c02998

Nanami Fujisawa, Lili Chen and Mitsuhiro Ebara*,

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Abstract

Diels–Alder chemistry was exploited to develop a remote-controllable drug release platform on magnetic nanoparticles (MNPs). For this purpose, MNPs were decorated with anionic poly(styrenesulfonic acid-co-furfuryl methacrylate) (poly(SS-co-FMA)) and cationic poly(allylamine hydrochloride) by layer-by-layer assembly. The decorated MNPs successfully underwent DA reaction to produce covalent bonding between FMA (diene) and maleimide (dienophile)-terminated model drug. Thermal treatment above 80 °C caused the retro Diels–Alder reaction (rDA) between FMA and the drug, resulting in drug release. The retro DA could be also achieved by applying an alternating-current (AC) magnetic field to the decorated MNPs. This could spatially limit the heat generation around MNP without heating entire system. Drug release could be also accelerated with the irradiation time when a threshold temperature was met or exceeded the required energy for rDA reaction. Our results highlight the potential of DA chemistry as a new strategy to provide a remote controllable drug release platform for improving the therapeutic efficiency.

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通过逐层组装在磁性纳米颗粒上设计可远程控制的 Diels-Alder 平台，实现交流磁场触发药物释放

研究人员利用 Diels-Alder 化学方法在磁性纳米粒子（MNPs）上开发了一种可远程控制的药物释放平台。为此，通过逐层组装，用阴离子聚（苯乙烯磺酸-甲基丙烯酸糠酯）（poly(SS-co-FMA)）和阳离子聚（盐酸烯丙胺）装饰了 MNPs。装饰后的 MNPs 成功地进行了 DA 反应，在 FMA（二烯）和马来酰亚胺（亲二烯）末端模型药物之间产生了共价键。80 °C 以上的热处理会导致 FMA 与药物之间发生逆向 Diels-Alder 反应（rDA），从而导致药物释放。对装饰过的 MNPs 施加交流磁场也能实现逆向 Diels-Alder 反应。这可以在不加热整个系统的情况下在空间上限制 MNP 周围的发热。当达到或超过 rDA 反应所需的能量阈值温度时，药物释放也会随着辐照时间的延长而加快。我们的研究结果凸显了 DA 化学作为一种新策略的潜力，它可以提供一种远程可控的药物释放平台，从而提高治疗效率。

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来源期刊

Langmuir 化学-材料科学：综合

CiteScore

6.50

自引率

10.30%

发文量

1464

审稿时长

2.1 months

期刊介绍： Langmuir is an interdisciplinary journal publishing articles in the following subject categories: Colloids: surfactants and self-assembly, dispersions, emulsions, foams Interfaces: adsorption, reactions, films, forces Biological Interfaces: biocolloids, biomolecular and biomimetic materials Materials: nano- and mesostructured materials, polymers, gels, liquid crystals Electrochemistry: interfacial charge transfer, charge transport, electrocatalysis, electrokinetic phenomena, bioelectrochemistry Devices and Applications: sensors, fluidics, patterning, catalysis, photonic crystals However, when high-impact, original work is submitted that does not fit within the above categories, decisions to accept or decline such papers will be based on one criteria: What Would Irving Do? Langmuir ranks #2 in citations out of 136 journals in the category of Physical Chemistry with 113,157 total citations. The journal received an Impact Factor of 4.384*. This journal is also indexed in the categories of Materials Science (ranked #1) and Multidisciplinary Chemistry (ranked #5).