The link between periodontitis and Alzheimer's disease – Brunei context

Archives of Gerontology and Geriatrics Plus Pub Date : 2024-11-12 DOI:10.1016/j.aggp.2024.100097

Sarah Nabihah Mohamad Fadzli , Jagjit Singh Dhaliwal , Faiza Alam , Jacqueline Kamaluddin , Hanif Abdul Rahman

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Abstract

Aim

The study aims to explore the relationship between periodontitis and Alzheimer's disease, focusing on the association and their potential impact on cognitive health.

Methods

A retrospective study was conducted utilizing data obtained from the Brunei Health Information Management System (Bru-HIMS). The research study examined the correlation between periodontitis and Alzheimer's disease in individuals admitted to government healthcare settings between January 2014 and December 2023. Logistic regression and survival analysis were applied.

Results

After diagnosis of periodontitis, 81.6 %, 59.2 % and 40.8 % developed Alzheimer's disease after 1–3- and 5-years, respectively. Women (34.3 %) had significantly lower proportion of developing Alzheimer's disease after 5 years compared to men (46.3 %). Furthermore, those with history of tooth extraction has a high risk of developing Alzheimer's disease (Adjusted Hazard Ratio = 5.00; 95 % CI: 2.04, 12.28; p < 0.001).

Conclusion

The study highlights the importance of understanding periodontal health in Alzheimer's patients and suggests further research and targeted interventions to mitigate its impact on cognitive function.

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牙周炎与阿尔茨海默病之间的联系 - 文莱背景

目的本研究旨在探讨牙周炎与阿尔茨海默病之间的关系，重点关注两者之间的关联及其对认知健康的潜在影响。方法本研究利用从文莱卫生信息管理系统（Bru-HIMS）中获取的数据开展了一项回顾性研究。研究调查了2014年1月至2023年12月期间政府医疗机构收治的牙周炎患者与阿尔茨海默病之间的相关性。结果确诊牙周炎后，分别有 81.6%、59.2% 和 40.8%的人在 1-3 年和 5 年后患上阿尔茨海默病。与男性（46.3%）相比，女性（34.3%）5 年后罹患阿尔茨海默病的比例明显较低。此外，有拔牙史的人罹患阿尔茨海默病的风险较高（调整危险比 = 5.00; 95 % CI: 2.04, 12.28; p < 0.001）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Archives of Gerontology and Geriatrics Plus

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