Chlorate in foodstuffs from south China and its implication for human exposure

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY Food and Chemical Toxicology Pub Date : 2024-11-19 DOI:10.1016/j.fct.2024.115120

Yining Chen , Zhou Zhu , Jiajia Ji , Yiming Ge , Shihua Zhong , Chan Nie , Shaoyou Lu

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Abstract

Chlorate, mainly used in the production of fireworks, herbicides and other products, is an inorganic pollutant, which easily dissolves in water and is difficult to degrade. Chlorate has a potential toxic risk to the thyroid function, kidneys, and blood system, which could pose a potential threat to human health. However, studies focusing on human exposure to chlorate are scarce, especially via food consumption. This study aimed to investigate the concentrations of chlorate in six types of foods (n = 531) from south China, and evaluate potential exposure risks for local residents. The detection rates of chlorate in all six types of foods were greater than 50 %, indicating the ubiquitous occurrence of chlorate in foods. Among the six types of foods, vegetables exhibited the highest concentrations of chlorate (p < 0.05), mainly attributed to the direct exposure to the environment compared with other foods. The hazard quotient (HQ) values by using EFSA reference dose (RfD) of chlorate via foods and water consumption existed greater than 1 in different age groups, indicating a potential health risks to human in south China.

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中国南方食品中的氯酸盐及其对人体接触的影响。

氯酸盐主要用于生产烟花、除草剂等产品，属于无机污染物，易溶于水，难以降解。氯酸盐对甲状腺功能、肾脏和血液系统有潜在的毒性风险，可能对人体健康构成潜在威胁。然而，有关人类接触氯酸盐（尤其是通过食物摄入）的研究却很少。本研究旨在调查华南地区六种食品（样本数=531）中氯酸盐的浓度，并评估当地居民可能摄入氯酸盐的风险。六种食物中氯酸盐的检出率均大于50%，表明氯酸盐在食物中无处不在。在六种食品中，蔬菜的氯酸盐含量最高（p < 0.05），这主要是由于蔬菜与其他食品相比直接暴露于环境所致。根据欧洲食物安全局的参考剂量（RfD）计算，不同年龄组人群通过食物和水摄入氯酸盐的危害商数值均大于1，这表明氯酸盐对华南地区的人体健康存在潜在风险。

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来源期刊

Food and Chemical Toxicology 工程技术-毒理学

CiteScore

10.90

自引率

4.70%

发文量

651

审稿时长

31 days

期刊介绍： Food and Chemical Toxicology (FCT), an internationally renowned journal, that publishes original research articles and reviews on toxic effects, in animals and humans, of natural or synthetic chemicals occurring in the human environment with particular emphasis on food, drugs, and chemicals, including agricultural and industrial safety, and consumer product safety. Areas such as safety evaluation of novel foods and ingredients, biotechnologically-derived products, and nanomaterials are included in the scope of the journal. FCT also encourages submission of papers on inter-relationships between nutrition and toxicology and on in vitro techniques, particularly those fostering the 3 Rs. The principal aim of the journal is to publish high impact, scholarly work and to serve as a multidisciplinary forum for research in toxicology. Papers submitted will be judged on the basis of scientific originality and contribution to the field, quality and subject matter. Studies should address at least one of the following: -Adverse physiological/biochemical, or pathological changes induced by specific defined substances -New techniques for assessing potential toxicity, including molecular biology -Mechanisms underlying toxic phenomena -Toxicological examinations of specific chemicals or consumer products, both those showing adverse effects and those demonstrating safety, that meet current standards of scientific acceptability. Authors must clearly and briefly identify what novel toxic effect (s) or toxic mechanism (s) of the chemical are being reported and what their significance is in the abstract. Furthermore, sufficient doses should be included in order to provide information on NOAEL/LOAEL values.