3D printing of drug delivery systems enhanced with micro/nano-technology

IF 15.2 1区医学 Q1 PHARMACOLOGY & PHARMACY Advanced drug delivery reviews Pub Date : 2024-11-26 DOI:10.1016/j.addr.2024.115479

Hui Zhu, Huijuan Kuang, Xinxin Huang, Xiao Li, Ruosen Zhao, Guojin Shang, Ziyu Wang, Yucheng Liao, Jiankang He, Dichen Li

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Abstract

Drug delivery systems (DDSs) are increasingly important in ensuring drug safety and enhancing therapeutic efficacy. Micro/nano-technology has been utilized to develop DDSs for achieving high stability, bioavailability, and drug efficiency, as well as targeted delivery; meanwhile, 3D printing technology has made it possible to tailor DDSs with diverse components and intricate structures. This review presents the latest research progress integrating 3D printing technology and micro/nano-technology for developing novel DDSs. The technological fundamentals of 3D printing technology supporting the development of DDSs are presented, mainly from the perspective of different 3D printing mechanisms. Distinct types of DDSs leveraging 3D printing and micro/nano-technology are analyzed deeply, featuring micro/nanoscale materials and structures to enrich functionalities and improve effectiveness. Finally, we will discuss the future directions of 3D-printed DDSs integrated with micro/nano-technology, focusing on technological innovation and clinical application. This review will support interdisciplinary research efforts to advance drug delivery technology.

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利用微/纳米技术增强给药系统的 3D 打印技术

给药系统（DDS）在确保药物安全和提高疗效方面的作用日益重要。微/纳米技术已被用于开发药物递送系统，以实现高稳定性、生物利用度和药物效率，以及靶向递送；同时，三维打印技术已使定制具有不同成分和复杂结构的药物递送系统成为可能。本综述介绍了结合三维打印技术和微米/纳米技术开发新型 DDS 的最新研究进展。主要从不同三维打印机制的角度介绍了支持 DDS 开发的三维打印技术的技术基础。深入分析了利用三维打印和微米/纳米技术开发的不同类型的 DDS，其特点是采用微米/纳米级材料和结构来丰富功能和提高效能。最后，我们将讨论三维打印 DDS 与微/纳米技术结合的未来发展方向，重点关注技术创新和临床应用。本综述将支持跨学科研究工作，推动给药技术的发展。

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来源期刊

Advanced drug delivery reviews 医学-药学

CiteScore

28.10

自引率

5.00%

发文量

294

审稿时长

15.1 weeks

期刊介绍： The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery. In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand. Importantly the Editorial Team of ADDR asks that the authors effectively window the extensive volume of literature, pick the important contributions and explain their importance, produce a forward looking identification of the challenges facing the field and produce a Conclusions section with expert recommendations to address the issues.