Multifunctional carboxymethyl chitosan-based sponges loaded with epigallocatechin-3-gallate for accelerating wound healing in diabetic rats with full-thickness burns

IF 10.7 1区 化学 Q1 CHEMISTRY, APPLIED Carbohydrate Polymers Pub Date : 2024-11-16 DOI:10.1016/j.carbpol.2024.123025
Yanting Wang, Ziming Zhu, Xiansen Lv, Baoqin Han, Zhiwen Jiang
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Abstract

Full-thickness burn wounds in diabetes often present significant challenges in terms of timely progression of healing and even mortality. Multifunctional dressings that possess strong absorptivity and mechanical property while effectively regulating inflammation and promoting angiogenesis is therefore crucial. We have developed a novel sponge (CCGE) comprising carboxymethyl chitosan, gelatin, and glycerin for the purpose of promoting accelerated healing of scald wounds in diabetic rats. This sponge is loaded with epigallocatechin-3-gallate, which possesses antioxidant and anti-inflammatory properties. The incorporation of the crosslinker BDDE reinforces its mechanical characteristics by augmenting the interplay between the sponge structure through hydrogen bonding and covalent bonding. Moreover, the crosslinked sponges provide a highly absorptive layer, carboxymethyl chitosan show good biocompatibility and angiogenic effects, and the gelatin provide matrix metalloproteinases-9 targeting. The CCGE sponges exhibit high biocompatibility, facilitate fibroblast migration, and promote tube formation. The application of the CCGE sponges significantly accelerates wound healing of full-thickness scald wounds in diabetic rats, exhibits enhanced collagen synthesis, reduced levels of pro-inflammatory cytokines, and increased blood vessel formation within the wounded area. In summary, this study presents a multifunctional composite CCGE sponge dressing that effectively modulates ROS, inflammation, and angiogenesis to facilitate comprehensive burn wound tissue repair in diabetes.

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含有表没食子儿茶素-3-棓酸盐的多功能羧甲基壳聚糖基海绵可加速全厚烧伤糖尿病大鼠的伤口愈合
糖尿病患者的全厚烧伤创面往往给及时愈合甚至死亡带来巨大挑战。因此,既具有强吸收性和机械性能,又能有效调节炎症和促进血管生成的多功能敷料至关重要。我们开发了一种由羧甲基壳聚糖、明胶和甘油组成的新型海绵(CCGE),用于促进糖尿病大鼠烫伤伤口的加速愈合。这种海绵含有表没食子儿茶素-3-棓酸盐,具有抗氧化和消炎作用。交联剂 BDDE 的加入通过氢键和共价键增强了海绵结构之间的相互作用,从而强化了其机械特性。此外,交联海绵提供了一个高吸收层,羧甲基壳聚糖显示出良好的生物相容性和血管生成效应,明胶提供了基质金属蛋白酶-9靶向性。CCGE 海绵具有很高的生物相容性,可促进成纤维细胞迁移,并促进管形成。使用 CCGE 海绵可明显加快糖尿病大鼠全厚烫伤伤口的愈合,促进胶原蛋白的合成,降低促炎细胞因子的水平,增加创面内血管的形成。总之,本研究提出了一种多功能复合 CCGE 海绵敷料,它能有效调节 ROS、炎症和血管生成,促进糖尿病烧伤创面组织的全面修复。
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来源期刊
Carbohydrate Polymers
Carbohydrate Polymers 化学-高分子科学
CiteScore
22.40
自引率
8.00%
发文量
1286
审稿时长
47 days
期刊介绍: Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.
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