Association between serum carotenoids and migraine in adults: a cross-sectional study from NHANES data.

IF 4.1 2区 医学 Q2 NUTRITION & DIETETICS European Journal of Nutrition Pub Date : 2024-11-28 DOI:10.1007/s00394-024-03550-4
Wenyuan Zhang, Zicheng Cheng, Fangwang Fu, Zhenxiang Zhan, Shuyue Lou, Saizhen Wu
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Abstract

Background: Little is known regarding the impact of serum carotenoids, a class of compounds having anti-inflammatory and antioxidant properties, on migraine. This study aimed to examine the association between serum carotenoid levels and migraine risk among United States adults.

Methods: This cross-sectional study recruited 7744 individuals aged 20 years or older from the National Health and Nutrition Examination Survey conducted between 2001 and 2004. The concentrations of five serum carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lycopene, and lutein + zeaxanthin) and retinol were measured using high-performance liquid chromatography. Migraine was diagnosed when participants reported that they had severe headaches or migraines during the past three months. Weighted multivariable logistic regression and restricted cubic spline models were used to determine the association between serum carotenoid levels and migraine risk.

Results: Among the 7744 participants enrolled in the study, 1595 (20.6%) had migraine. Compared with the lowest quartiles, the highest quartiles of the three serum carotenoids were associated with a lower risk of migraine, with a multivariable-adjusted odds ratio (OR) of 0.74 (95% confidence interval [CI], 0.57-0.97) for α-carotene, 0.64 (95% CI, 0.49-0.83) for β-carotene, and 0.64 (95% CI, 0.53-0.78) for lutein + zeaxanthin, while the third quartile of serum β-cryptoxanthin had lower odds of migraine (OR, 0.70; 95% CI, 0.54-0.90). The U-shaped patterns of nonlinear relationships between serum β-cryptoxanthin and lutein + zeaxanthin levels and migraine risk were represented by restricted cubic splines. No association was observed between serum lycopene and retinol levels and migraine.

Conclusions: Low serum carotenoid levels were associated with an increased risk of migraine. Further prospective investigations are warranted to clarify the causative relationship and explore the possible prevention and treatment of migraine using carotenoid supplementation.

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成人血清类胡萝卜素与偏头痛之间的关系:一项来自 NHANES 数据的横断面研究。
背景:血清类胡萝卜素是一类具有抗炎和抗氧化特性的化合物,人们对血清类胡萝卜素对偏头痛的影响知之甚少。本研究旨在探讨美国成年人血清类胡萝卜素水平与偏头痛风险之间的关系:这项横断面研究从 2001 年至 2004 年进行的全国健康与营养调查中招募了 7744 名 20 岁或以上的人。采用高效液相色谱法测量了五种血清类胡萝卜素(α-胡萝卜素、β-胡萝卜素、β-隐黄素、番茄红素和叶黄素 + 玉米黄质)和视黄醇的浓度。当参与者报告在过去三个月中有严重头痛或偏头痛时,即可诊断为偏头痛。加权多变量逻辑回归和限制性立方样条模型用于确定血清类胡萝卜素水平与偏头痛风险之间的关系:在参加研究的 7744 名参与者中,有 1595 人(20.6%)患有偏头痛。与最低四分位数相比,三种血清类胡萝卜素的最高四分位数与较低的偏头痛风险相关,α-类胡萝卜素的多变量调整赔率(OR)为 0.74(95% 置信区间 [CI],0.57-0.97)。α-胡萝卜素为 0.74(95% 置信区间 [CI],0.57-0.97),β-胡萝卜素为 0.64(95% 置信区间 [CI],0.49-0.83),叶黄素 + 玉米黄质为 0.64(95% 置信区间 [CI],0.53-0.78)。血清β-隐黄素和叶黄素+玉米黄质水平与偏头痛风险之间的非线性关系呈 "U "形,用受限立方样条表示。血清番茄红素和视黄醇水平与偏头痛之间没有关联:结论:血清类胡萝卜素水平低与偏头痛风险增加有关。结论:血清类胡萝卜素水平低与偏头痛风险增加有关,有必要进行进一步的前瞻性研究,以明确两者之间的因果关系,并探索使用类胡萝卜素补充剂预防和治疗偏头痛的可能性。
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来源期刊
CiteScore
10.20
自引率
2.00%
发文量
295
审稿时长
6 months
期刊介绍: The European Journal of Nutrition publishes original papers, reviews, and short communications in the nutritional sciences. The manuscripts submitted to the European Journal of Nutrition should have their major focus on the impact of nutrients and non-nutrients on immunology and inflammation, gene expression, metabolism, chronic diseases, or carcinogenesis, or a major focus on epidemiology, including intervention studies with healthy subjects and with patients, biofunctionality of food and food components, or the impact of diet on the environment.
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