Antimüllerian hormone and antral follicle count thresholds for hyperresponse risk assessment in in vitro fertilization: a Hyperresponse Risk Assessment consensus study.

IF 6.6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Fertility and sterility Pub Date : 2024-11-26 DOI:10.1016/j.fertnstert.2024.11.021
Alyssa Hochberg, Sandro C Esteves, Hakan Yarali, Lan N Vuong, Michael H Dahan
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Abstract

Objective: To determine the serum antimüllerian hormone (AMH) and antral follicle count (AFC) thresholds indicating an increased risk of hyperresponse to ovarian stimulation (OS) during in vitro fertilization, as defined by the Hyperresponse Risk Assessment (HERA) Delphi Consensus.

Design: A retrospective multicenter cohort study.

Setting: Three fertility centers.

Patient(s): Women with normal ovarian reserve markers according to the POSEIDON criteria (AMH level of ≥1.2 ng/mL and AFC of ≥5) undergoing their first in vitro fertilization/ intracytoplasmic sperm injection cycle with conventional OS (follicle-stimulating hormone [FSH] level of ≥150 IU/d) using the gonadotropin-releasing hormone antagonist protocol (2015-2017) were included.

Intervention(s): Hyperresponse was defined as ≥15 retrieved oocytes, on the basis of the HERA definition, compared with non-HERA hyperresponders, defined as patients with ovarian reserve markers within the normal range per the POSEIDON criteria and with <15 oocytes retrieved.

Main outcome measure(s): The primary outcome was the AMH and AFC threshold values, indicating an increased risk of a hyperresponse, using receiver operator characteristic curves. Outcomes were further stratified by patients' age (<35 and ≥35 years). Multivariable logistic regression explored factors associated with an HERA hyperresponse.

Result(s): A total of 4,220 patients were included, of whom 2,132 (50.5%) were hyperresponders. Receiver operator characteristic curves revealed the following thresholds for a hyperresponse: AMH level of ≥4.38 ng/mL (area under the curve [AUC], 0.71) and AFC of ≥16 (AUC, 0.80) for the entire cohort; AMH level of ≥4.95 ng/mL (AUC, 0.68) and AFC of ≥18 (AUC, 0.76) for women aged <35 years (N = 3,056); and AMH level of ≥4.33 ng/mL (AUC, 0.77) and AFC of ≥15 (AUC, 0.86) for women aged ≥35 years (N = 1,164). Older women received higher median daily and total FSH doses than younger women. The AMH, AFC, female age, daily/total gonadotropin dose, type of gonadotropin, and trigger strategy were significant predictors for hyperresponse.

Conclusion(s): The AMH and AFC values at and above these thresholds warrant increased caution when planning gonadotropin dosing, regimen, and trigger strategies before OS. These thresholds were lower in older women, potentially due to higher FSH dosing in this population.

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试管婴儿高反应风险评估中的抗苗勒氏管激素和前卵泡计数阈值:HERA 共识研究。
目的根据HERA(高反应风险评估)德尔菲共识的定义,确定表明体外受精(IVF)期间卵巢刺激(OS)高反应风险增加的血清抗苗勒管激素(AMH)和前卵泡计数(AFC)阈值:设计:一项回顾性多中心队列研究:研究对象:根据波塞冬标准(AMH≥1.2ng/mL且AFC≥5),卵巢储备指标正常的女性,使用GnRH-拮抗剂方案(2015-2017年),在常规OS(卵泡刺激素(FSH)≥150IU/天)下进行首个IVF/ICSI周期。暴露:根据 HERA 定义,与非 HERA 高反应者(根据 POSEIDON 标准,卵巢储备标志物在正常范围内且主要结局指标为正常)相比,高反应者的定义为检索到的卵母细胞≥15 个:主要结果是AMH和AFC阈值,利用接收器操作者特征曲线(ROC)表示高反应风险增加。根据患者年龄对结果进行进一步分层(结果:共纳入 4220 例患者,其中 2132 例(50.5%)为高反应者。ROC 曲线显示高反应阈值如下:整个队列的 AMH≥4.38ng/mL (AUC 0.71)和 AFC≥16 (AUC 0.80);女性的 AMH≥4.95ng/mL (AUC 0.68)和 AFC≥18 (AUC 0.76 结论:在 OS 前计划促性腺激素剂量、方案和触发策略时,AMH 和 AFC 值达到或超过这些阈值时应更加谨慎。这些阈值在老年妇女中较低,可能是由于老年妇女的 FSH 剂量较高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Fertility and sterility
Fertility and sterility 医学-妇产科学
CiteScore
11.30
自引率
6.00%
发文量
1446
审稿时长
31 days
期刊介绍: Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.
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