A cross-season analysis of S100B as a potential marker of concussion in professional rugby players.

IF 1.5 4区医学 Q4 NEUROSCIENCES Brain injury Pub Date : 2025-03-21 Epub Date: 2024-12-02 DOI:10.1080/02699052.2024.2429700

Áine M Kelly, Clíodhna McHugh, James Hale, Joice Cunningham, Noreen Boyle, Oisín Joyce, Brendan O'Connell, Gareth Farrell, Fiona Wilson

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Abstract

Objectives: To investigate the effect of multiple seasons of play on serum S100B concentration in male professional rugby players, while also assessing the acute effects following a season of play and concussion.

Methods: A prospective study of professional male rugby players over three seasons (2016/17 to 2018/19) was conducted. Serum sampling was carried out during pre-season, post-season and following a concussion; sustained during match play at a home game (between 2-24hrs), during each season. Serum S100B concentrations were determined by ELISA assay.

Results: Fourteen players sustained 24 concussions over three seasons, of which 13 samples (54%) were collected. Pre- and post-season serum S100B remained stable across multiple seasons. S100B concentration increased significantly following concussion compared with pre-season (p = 0.002) and post-season (p = 0.009), reflective in a 3.23-fold-change post-concussion, with no difference found between pre- and post-season values. S100B concentration measured at post-season was not significantly different for players who had a concussion during a season and players who did not.

Conclusion: S100B remains stable across multiple seasons of play in professional rugby players. As concussion results in a temporary increase in S100B concentration, returning to pre-season values by post-season, S100B may be a useful diagnostic marker for improving existing management protocols for sports-related concussions.

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S100B作为职业橄榄球运动员脑震荡潜在标志的跨赛季分析。

目的：探讨多赛季比赛对男性职业橄榄球运动员血清S100B浓度的影响，同时评估一个赛季比赛和脑震荡后的急性影响。方法：对2016/17 - 2018/19三个赛季的职业男子橄榄球运动员进行前瞻性研究。在赛季前、赛季后和脑震荡后进行血清取样；在每个赛季的主场比赛中持续（2-24小时）。ELISA法测定血清S100B浓度。结果：14名球员在3个赛季中发生24次脑震荡，其中13例（54%）被采集。季前和季后血清S100B在多个季节保持稳定。与赛季前（p = 0.002）和赛季后（p = 0.009）相比，脑震荡后S100B浓度显著增加，反映出脑震荡后的3.23倍变化，而赛季前和赛季后的值没有差异。在赛季中有脑震荡的球员和没有脑震荡的球员在赛季后测量的S100B浓度没有显著差异。结论：S100B在职业橄榄球运动员的多个赛季中保持稳定。由于脑震荡导致S100B浓度暂时升高，在赛季结束后恢复到赛季前的值，因此S100B可能是一个有用的诊断指标，可用于改进现有的运动相关脑震荡管理方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain injury 医学-康复医学

CiteScore

3.50

自引率

5.30%

发文量

148

审稿时长

12 months

期刊介绍： Brain Injury publishes critical information relating to research and clinical practice, adult and pediatric populations. The journal covers a full range of relevant topics relating to clinical, translational, and basic science research. Manuscripts address emergency and acute medical care, acute and post-acute rehabilitation, family and vocational issues, and long-term supports. Coverage includes assessment and interventions for functional, communication, neurological and psychological disorders.