Palladium-Catalyzed Decarboxylative Domino Synthesis of Fused Quinolin-2(1H)-one Scaffolds Containing Perfluoroalkyl Unit

Abstract

A novel palladium-catalyzed domino radical cyclization and C-H activation/decarboxylation of 1,7-enynes with o-bromobenzoic acids and perfluoroalkyl iodides has been developed for the expedite construction of fused perfluoroalkyl-containing quinolin-2(1H)-one scaffolds. This method provides a facile synthesis of fused quinolin-2(1H)-one derivatives containing perfluoroalkyl unit in high yields. Notably, the late-stage modifications of various drugs were also demonstrated by using this method.