The Potential Effect of Endogenous Antimicrobial Peptides in Cancer Immunotherapy and Prevention

IF 1.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Peptide Science Pub Date : 2024-12-23 DOI:10.1002/psc.3664

Tuan Hiep Tran, Thanh Huong Le, Thi Thu Phuong Tran

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Abstract

Antimicrobial peptides (AMPs) are crucial constituents of inherent immunity and serve as vital components of human host defense, playing a pivotal role in combating invading microbial pathogens. Beyond their antimicrobial functions, AMPs also exhibit various other biological activities including apoptosis induction, wound healing promotion, and immune modulation. These peptides are found in various exposed tissues or surfaces throughout the body, such as eyes, skin, mouth, ears, respiratory tract, lungs, digestive, and urinary system. Additionally, certain AMPs such as LL-37, HNP, and lactoferrin have shown potential as candidates for anticancer activity. Given the limited selectivity between normal and cancer cells exhibited by many current immunotherapeutic agents, the inherent properties of AMPs make them promising candidates for cancer treatment. Their abundance, bioavailability, safety profile, efficiency, and harmony with the host immune system position them as attractive tools in the fight against cancer. This review is aimed at exploring the potential anticancer properties of AMPs and elucidating their relationship with immunology and cancer immunotherapy.

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内源性抗菌肽在肿瘤免疫治疗和预防中的潜在作用。

抗菌肽是人体固有免疫的重要组成部分，是人体宿主防御的重要组成部分，在对抗入侵的微生物病原体中起着关键作用。除了抗菌功能外，amp还具有多种其他生物活性，包括诱导细胞凋亡、促进伤口愈合和免疫调节。这些多肽存在于全身各种暴露的组织或表面，如眼睛、皮肤、口腔、耳朵、呼吸道、肺部、消化系统和泌尿系统。此外，某些amp如LL-37、HNP和乳铁蛋白已显示出潜在的抗癌活性候选物。鉴于目前许多免疫治疗剂在正常细胞和癌细胞之间表现出有限的选择性，amp的固有特性使其成为癌症治疗的有希望的候选者。它们的丰度、生物利用度、安全性、效率以及与宿主免疫系统的协调性使它们成为对抗癌症的有吸引力的工具。本文旨在探讨amp的潜在抗癌特性，并阐明其与免疫学和癌症免疫治疗的关系。

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来源期刊

Journal of Peptide Science 生物-分析化学

CiteScore

3.40

自引率

4.80%

发文量

审稿时长

1.7 months

期刊介绍： The official Journal of the European Peptide Society EPS The Journal of Peptide Science is a cooperative venture of John Wiley & Sons, Ltd and the European Peptide Society, undertaken for the advancement of international peptide science by the publication of original research results and reviews. The Journal of Peptide Science publishes three types of articles: Research Articles, Rapid Communications and Reviews. The scope of the Journal embraces the whole range of peptide chemistry and biology: the isolation, characterisation, synthesis properties (chemical, physical, conformational, pharmacological, endocrine and immunological) and applications of natural peptides; studies of their analogues, including peptidomimetics; peptide antibiotics and other peptide-derived complex natural products; peptide and peptide-related drug design and development; peptide materials and nanomaterials science; combinatorial peptide research; the chemical synthesis of proteins; and methodological advances in all these areas. The spectrum of interests is well illustrated by the published proceedings of the regular international Symposia of the European, American, Japanese, Australian, Chinese and Indian Peptide Societies.