Additively manufactured ready-to-use platform using conductive recycled PLA for ketamine sensing

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL Microchimica Acta Pub Date : 2025-01-09 DOI:10.1007/s00604-024-06902-3

Maria M. C. Souza, Raquel G. Rocha, Gilvana P. Siqueira, Robert D. Crapnell, Eduardo M. Richter, Craig E. Banks, Rodrigo A. A. Muñoz

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Abstract

The use of 3D-printed electrodes is reported fabricated from in-house conductive filament composed of a mixture of recycled poly (lactic acid) (rPLA), graphite (Gpt), and carbon black (CB) for fast detection of the abused drug ketamine. Firstly, the performance of these electrodes was evaluated in comparison to 3D-printed electrodes produced employing a commercially available conductive filament. After a simple pretreatment step (mechanical polishing), the new 3D-printed electrodes presented better performance than the electrodes produced from commercial filament in relation to peak-to-peak separation of the redox probe [Fe(CN)₆]^3-/^4- (130 mV and 759 mV, respectively), charge transfer resistance (R_ct = 1.04 ± 0.05 kΩ and 9.62 ± 0.03 kΩ, respectively), and heterogeneous rate constant (k⁰ = 7.16 ± 0.05 × 10^–3 cm s⁻¹ and 3.57 ± 0.03 × 10^–3 cm s^-1, respectively). Excellent analytical characteristics for the detection of ketamine were achieved, including wide linear range (10 to 250 μmol L^-1), excellent sensitivity (0.024 ± 0.001 μA μmol L^-1), low limit of detection (LOD = 0.7 μmol L^-1), and recovery values from 82 to 115% for beverage samples (white and red wines, beer, water, and vodka) spiked with the abused drug ketamine.

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增材制造即用型平台，使用导电回收PLA用于氯胺酮传感

据报道，3d打印电极的使用是由内部导电丝制成的，导电丝由回收聚乳酸（rPLA）、石墨（Gpt）和炭黑（CB）的混合物组成，用于快速检测滥用药物氯胺酮。首先，将这些电极的性能与采用市售导电灯丝生产的3d打印电极进行了比较。经过简单的预处理步骤（机械抛光），新型3d打印电极在氧化还原探针[Fe(CN)6]3-/4-的峰间分离（分别为130 mV和759 mV）、电荷转移电阻（Rct分别为1.04±0.05 kΩ和9.62±0.03 kΩ）和非均相速率常数（k0分别为7.16±0.05 × 10-3 cm s-1和3.57±0.03 × 10-3 cm s-1）方面均优于商业丝电极。氯胺酮的线性范围宽（10 ~ 250 μmol L-1），灵敏度高（0.024±0.001 μA μmol L-1），检出限低（LOD = 0.7 μmol L-1），加氯胺酮的饮料样品（白酒、红酒、啤酒、水、伏特加）回收率为82% ~ 115%。图形抽象

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.