Development of biomaterials for bone tissue engineering based on bile acids

IF 4.2 3区医学 Q2 ENGINEERING, BIOMEDICAL Journal of Materials Science: Materials in Medicine Pub Date : 2025-01-15 DOI:10.1007/s10856-024-06850-7

Yongjun Liu, Xiaojie Liu, Chang Liu, Wenan Zhang, Ting Shi, Guanying Liu

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Abstract

Diseases and injuries can cause significant bone loss, leading to increased medical expenses, decreased work efficiency, and a decline in quality of life. Bone tissue engineering (BTE) is gaining attention as an alternative to autologous and allogeneic transplantation due to the limited availability of donors. Biomaterials represent a promising strategy for bone regeneration, and their design should consider the three key processes in bone tissue engineering: osteogenesis, bone conduction, and bone induction. Certain bile acids (BAs) demonstrate significant antioxidant, anti-inflammatory, and immunosuppressive properties, and effectively promote bone and tissue regeneration. Additionally, the combination of BA molecule with other biological materials can help overcome problems associated with limited local bone regeneration and maintain a defined release state for a long time. Thus in this review, we focus on the role and the mechanism of bile acids in bone healing under different conditions, highlighting their unique properties and applications in gel fabrication, microencapsulation, and nanotechnology. These advancements serve as a basis for the advancement of biomaterials derived from BAs, specifically for the purpose of bone reconstruction.

Graphical Abstract

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胆汁酸类骨组织工程生物材料的研究进展。

疾病和伤害会导致严重的骨质流失，导致医疗费用增加，工作效率下降，生活质量下降。由于供体有限，骨组织工程（BTE）作为自体和异体移植的替代方法越来越受到关注。生物材料是一种很有前途的骨再生策略，其设计应考虑骨组织工程中的三个关键过程：成骨、骨传导和骨诱导。某些胆汁酸（BAs）显示出显著的抗氧化、抗炎和免疫抑制特性，并有效地促进骨和组织再生。此外，BA分子与其他生物材料的结合可以帮助克服局部骨再生受限的问题，并长期保持一定的释放状态。因此，本文将重点介绍胆汁酸在不同条件下骨愈合中的作用和机制，重点介绍胆汁酸的独特性质及其在凝胶制备、微胶囊化和纳米技术方面的应用。这些进展为BAs衍生生物材料的发展奠定了基础，特别是用于骨重建。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Materials Science: Materials in Medicine 工程技术-材料科学：生物材料

CiteScore

8.00

自引率

0.00%

发文量

审稿时长

3.5 months

期刊介绍： The Journal of Materials Science: Materials in Medicine publishes refereed papers providing significant progress in the application of biomaterials and tissue engineering constructs as medical or dental implants, prostheses and devices. Coverage spans a wide range of topics from basic science to clinical applications, around the theme of materials in medicine and dentistry. The central element is the development of synthetic and natural materials used in orthopaedic, maxillofacial, cardiovascular, neurological, ophthalmic and dental applications. Special biomedical topics include biomaterial synthesis and characterisation, biocompatibility studies, nanomedicine, tissue engineering constructs and cell substrates, regenerative medicine, computer modelling and other advanced experimental methodologies.