Current Concepts and Clinical Applications in Cartilage Tissue Engineering.

IF 3.5 3区 医学 Q3 CELL & TISSUE ENGINEERING Tissue Engineering Part A Pub Date : 2025-02-01 Epub Date: 2025-01-15 DOI:10.1089/ten.tea.2024.0300
Connor Wright, Serafina Faith Zotter, Wei Shao Tung, Kristen Reikersdorfer, Andrew Homer, Nadim Kheir, Nikolaos Paschos
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Abstract

Cartilage injuries are extremely common in the general population, and conventional interventions have failed to produce optimal results. Tissue engineering (TE) technology has been developed to produce neocartilage for use in a variety of cartilage-related conditions. However, progress in the field of cartilage TE has historically been difficult due to the high functional demand and avascular nature of the tissue. Recent advancements in cell sourcing, biostimulation, and scaffold technology have revolutionized the field and made the clinical application of this technology a reality. Cartilage engineering technology will continue to expand its horizons to fully integrate three-dimensional printing, gene editing, and optimal cell sourcing in the future. This review focuses on the recent advancements in the field of cartilage TE and the landscape of clinical treatments for a variety of cartilage-related conditions.

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软骨组织工程的概念与临床应用
软骨损伤在普通人群中非常常见,传统的干预措施未能产生最佳效果。组织工程(TE)技术已经发展到生产用于各种软骨相关疾病的新软骨。然而,由于组织的高功能要求和无血管性质,软骨TE领域的进展一直很困难。最近在细胞来源、生物刺激和支架技术方面的进步彻底改变了这一领域,并使这项技术的临床应用成为现实。未来,软骨工程技术将继续拓展其视野,充分整合三维打印、基因编辑和最佳细胞来源。本文综述了软骨TE领域的最新进展以及各种软骨相关疾病的临床治疗前景。
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来源期刊
Tissue Engineering Part A
Tissue Engineering Part A Chemical Engineering-Bioengineering
CiteScore
9.20
自引率
2.40%
发文量
163
审稿时长
3 months
期刊介绍: Tissue Engineering is the preeminent, biomedical journal advancing the field with cutting-edge research and applications that repair or regenerate portions or whole tissues. This multidisciplinary journal brings together the principles of engineering and life sciences in the creation of artificial tissues and regenerative medicine. Tissue Engineering is divided into three parts, providing a central forum for groundbreaking scientific research and developments of clinical applications from leading experts in the field that will enable the functional replacement of tissues.
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