{"title":"Turning down the heat in NEPC","authors":"Louise Lloyd","doi":"10.1038/s41585-025-00995-y","DOIUrl":null,"url":null,"abstract":"<p>Heat shock protein 60 (HSP60), the main chaperone of the mitochondrial unfolded protein response, could be a potential therapeutic target in neuroendocrine prostate cancer (NEPC). Preclinical evidence shows that HSP60 inhibition reduces NEPC growth in vivo.</p><p>In the TRAMP mouse model, oxidative phosphorylation complex activity was dysfunctional in mitochondrial fractions from tumour samples. The mitochondrial unfolded protein response, assessed using HSP60 as a surrogate readout, was increased in several models of aggressive prostate cancer and patient sample datasets.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"68 1","pages":""},"PeriodicalIF":12.1000,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Urology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41585-025-00995-y","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Heat shock protein 60 (HSP60), the main chaperone of the mitochondrial unfolded protein response, could be a potential therapeutic target in neuroendocrine prostate cancer (NEPC). Preclinical evidence shows that HSP60 inhibition reduces NEPC growth in vivo.
In the TRAMP mouse model, oxidative phosphorylation complex activity was dysfunctional in mitochondrial fractions from tumour samples. The mitochondrial unfolded protein response, assessed using HSP60 as a surrogate readout, was increased in several models of aggressive prostate cancer and patient sample datasets.
期刊介绍：
Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline.
The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals.
Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.
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