The interaction between orexin, sleep deprivation and Alzheimer's disease: Unveiling an Emerging Connection.

IF 2.6 4区医学 Q2 PHYSIOLOGY Journal of Physiological Sciences Pub Date : 2025-01-02 DOI:10.1016/j.jphyss.2024.100004

Masoumeh Kourosh-Arami, Mahdi Ramezani, Alireza Komaki

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Abstract

Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by progressive cognitive decline and memory loss. Sleep-wake disorders are an extremely predominant and often disabling aspect of AD. Ox is vital in maintaining the sleep-wake cycle and promoting wakefulness. Dysfunction of Ox signaling has been associated with sleep disorders such as narcolepsy. In AD patients, the increase in cerebrospinal fluid Ox levels is related to parallel sleep deterioration. The relationship between AD and sleep disturbances has gained increasing attention due to their potential bidirectional influence. Disruptions in sleep patterns are commonly observed in AD patients, leading researchers to investigate the possible involvement of Ox in sleep disturbances characteristic of the disease. This review article explores the role of the Ox system in AD, and the intricate relationship between AD and sleep, highlighting the potential mechanisms, impact on disease pathology, and therapeutic interventions to improve sleep quality in affected individuals.

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食欲素、睡眠剥夺和阿尔茨海默病之间的相互作用：揭示一种新兴的联系。

阿尔茨海默病（AD）是一种破坏性的神经退行性疾病，其特征是进行性认知能力下降和记忆丧失。睡眠-觉醒障碍是阿尔茨海默病的一个非常主要和经常致残的方面。牛对维持睡眠-觉醒周期和促进清醒至关重要。Ox信号的功能障碍与睡眠障碍如嗜睡症有关。在AD患者中，脑脊液Ox水平的增加与平行睡眠恶化有关。阿尔茨海默病与睡眠障碍之间的关系因其潜在的双向影响而越来越受到关注。睡眠模式中断在AD患者中很常见，这促使研究人员调查了Ox可能与该疾病特征的睡眠障碍有关。本文综述了Ox系统在AD中的作用，以及AD与睡眠之间的复杂关系，重点介绍了AD的潜在机制、对疾病病理的影响以及改善患者睡眠质量的治疗干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Physiological Sciences 医学-生理学

CiteScore

4.40

自引率

4.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Physiological Sciences publishes peer-reviewed original papers, reviews, short communications, technical notes, and letters to the editor, based on the principles and theories of modern physiology and addressed to the international scientific community. All fields of physiology are covered, encompassing molecular, cellular and systems physiology. The emphasis is on human and vertebrate physiology, but comparative papers are also considered. The process of obtaining results must be ethically sound. Fields covered: Adaptation and environment Autonomic nervous function Biophysics Cell sensors and signaling Central nervous system and brain sciences Endocrinology and metabolism Excitable membranes and neural cell physiology Exercise physiology Gastrointestinal and kidney physiology Heart and circulatory physiology Molecular and cellular physiology Muscle physiology Physiome/systems biology Respiration physiology Senses.