Role of cumulus–oocyte interactions in fertility

IF 3.9 3区 农林科学 Q1 VETERINARY SCIENCES Lab Animal Pub Date : 2025-02-03 DOI:10.1038/s41684-025-01513-8
Alexandra Le Bras
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卵丘-卵母细胞相互作用在生育中的作用
生物女性生殖老化的特点是卵巢功能的逐渐下降,最终达到更年期。生育能力通常在35岁以后下降,40岁以后怀孕更少,这表明绝经前女性生殖道的变化已经发生,对生殖成功产生了负面影响。《通讯生物学》上的一项研究表明,透明带(ZP)的结构变化——发育中的卵母细胞周围的特殊细胞外基质——会降低中年(34 - 38周龄)雌性小鼠的生育能力。研究人员特别观察到,与年轻小鼠相比,中年小鼠的跨区突起(连接卵丘细胞和卵母细胞的薄细胞质突起)有所减少。这种变化与积云细胞-卵母细胞相互作用的减少有关,导致卵母细胞质量的恶化。研究小组还发现了中年小鼠ZP表面的结构变化,这种变化阻止了精子的结合。总之,这些结果表明,与年龄相关的卵母细胞-积云沟通不良会损害ZP的形成,降低中年女性的生育能力。原始参考文献:Ishikawa-Yamauchi, Y.等。Commun。生物学报,1692 (2024)
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来源期刊
Lab Animal
Lab Animal 农林科学-兽医学
CiteScore
0.60
自引率
2.90%
发文量
181
审稿时长
>36 weeks
期刊介绍: LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research. LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.
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