The L-shaped association between body roundness index and all-cause mortality in osteoporotic patients: a cohort study based on NHANES data.

IF 4 2区农林科学 Q2 NUTRITION & DIETETICS Frontiers in Nutrition Pub Date : 2025-01-20 eCollection Date: 2025-01-01 DOI:10.3389/fnut.2025.1538766

Ziyao Ding, Wenbo Li, Haixu Qi, Tianci Fang, Qirui Zhu, Xinzhe Qu, Changchang Chen, Jun Sun, Yong Pang

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Abstract

Purpose: This study aims to investigate the relationship between the body roundness index (BRI) and overall mortality rates in individuals with osteoporosis (OP), utilizing information sourced from the NHANES database, in order to assess BRI's capability as an indicator for predicting mortality risk.

Methods: Data from NHANES (2005 to 2010, 2013-2014, and 2017-2018) were analyzed, including 1,596 osteoporotic individuals aged 50 and above. BRI was calculated based on waist circumference (WC) and height, categorizing participants into high (>4.07) and low (≤4.07) BRI groups. To analyze the relationship between BRI and mortality while accounting for important covariates, we employed weighted Cox proportional hazards models, conducted Kaplan-Meier survival analyses, and utilized restricted cubic splines (RCS).

Results: Higher BRI was significantly associated with better long-term survival, showing an "L"-shaped nonlinear inverse relationship with mortality, with a threshold at BRI = 5. In subgroup analyses, this association remained relatively stable.

Conclusion: The "L"-shaped association between BRI and mortality indicates that BRI may serve as a useful indicator for evaluating mortality risk in patients with OP, thereby informing clinical interventions and public health approaches.

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骨质疏松症患者体圆指数与全因死亡率之间的 L 型关联：基于 NHANES 数据的队列研究。

目的：本研究旨在利用来自NHANES数据库的信息，探讨骨质疏松症（OP）患者身体圆度指数（BRI）与总体死亡率之间的关系，以评估BRI作为预测死亡风险指标的能力。方法：分析NHANES（2005 - 2010年、2013-2014年和2017-2018年）的数据，包括1596名50岁及以上的骨质疏松患者。根据腰围（WC）和身高计算BRI，将参与者分为高（>4.07）和低（≤4.07）BRI组。为了分析BRI与死亡率之间的关系，同时考虑重要的协变量，我们采用加权Cox比例风险模型，进行Kaplan-Meier生存分析，并利用限制三次样条（RCS）。结果：较高的BRI与较好的长期生存率显著相关，与死亡率呈“L”形非线性负相关，其阈值为BRI = 5。在亚组分析中，这种关联保持相对稳定。结论：BRI与死亡率呈“L”型关系，表明BRI可作为评估OP患者死亡风险的有用指标，从而为临床干预和公共卫生方法提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

5.20

自引率

8.00%

发文量

2891

审稿时长

12 weeks

期刊介绍： No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.