A novel xanthene-based NIR fluorescent probe for the high-sensitivity detection of UO₂2⁺ in the blood from mice eyeballs

IF 4.2 3区工程技术 Q2 CHEMISTRY, APPLIED Dyes and Pigments Pub Date : 2025-04-01 Epub Date: 2024-12-24 DOI:10.1016/j.dyepig.2024.112618

Jinting Shang , Lufang Su , Liping Li , Xin Yu , Yan Yang , Chen Wang , Jingran Wang , Xuannan Zhang , Yuran Gui , Wei Liu , Yiyuan Xia , Xiji Shu , Yibin Zhang

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Abstract

The radiotoxicity and chemical toxicity of UO₂²⁺ pose a long-term threat to ecosystems and human health through bioaccumulation and biomagnification. Therefore, there is an urgent need to develop highly sensitive and selective detection methods for UO₂²⁺. Here, we developed a near-infrared (NIR) fluorescent probe RU, built on a xanthene core structure. Upon binding with UO₂²⁺, RU undergoes ring-opening, triggering fluorescence turn on. RU exhibited high selectivity, sensitivity, and rapid response toward UO₂²⁺. Besides, we have successfully employed RU to visualize UO₂²⁺ in the blood of mice's eyeballs for the first time, providing a valuable method to investigate its biological behavior and toxicity in living system.

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一种新型的基于杂蒽的近红外荧光探针，用于高灵敏度检测小鼠眼球血液中的UO₂2 +

UO₂2 +的放射毒性和化学毒性通过生物蓄积和生物放大作用对生态系统和人类健康构成长期威胁。因此，迫切需要开发出高灵敏度、高选择性的UO₂2⁺检测方法。在这里，我们开发了一种基于杂蒽核心结构的近红外（NIR）荧光探针RU。与UO₂2 +结合后，RU发生开环，触发荧光开启。RU对UO 2 +表现出高选择性、高灵敏度和快速响应。此外，我们首次成功地利用RU在小鼠眼球血液中可视化了UO 2 +，为研究其在生命系统中的生物学行为和毒性提供了一种有价值的方法。

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.