A novel xanthene-based NIR fluorescent probe for the high-sensitivity detection of UO₂2⁺ in the blood from mice eyeballs

IF 4.1 3区工程技术 Q2 CHEMISTRY, APPLIED Dyes and Pigments Pub Date : 2024-12-24 DOI:10.1016/j.dyepig.2024.112618

Jinting Shang , Lufang Su , Liping Li , Xin Yu , Yan Yang , Chen Wang , Jingran Wang , Xuannan Zhang , Yuran Gui , Wei Liu , Yiyuan Xia , Xiji Shu , Yibin Zhang

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引用次数: 0

Abstract

The radiotoxicity and chemical toxicity of UO₂²⁺ pose a long-term threat to ecosystems and human health through bioaccumulation and biomagnification. Therefore, there is an urgent need to develop highly sensitive and selective detection methods for UO₂²⁺. Here, we developed a near-infrared (NIR) fluorescent probe RU, built on a xanthene core structure. Upon binding with UO₂²⁺, RU undergoes ring-opening, triggering fluorescence turn on. RU exhibited high selectivity, sensitivity, and rapid response toward UO₂²⁺. Besides, we have successfully employed RU to visualize UO₂²⁺ in the blood of mice's eyeballs for the first time, providing a valuable method to investigate its biological behavior and toxicity in living system.

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.