Bridging the gap to clinical use: A systematic review on TMS–EEG test-retest reliability

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2025-01-23 DOI:10.1016/j.clinph.2025.01.002

Giacomo Bertazzoli , Elisa Dognini , Peter J. Fried , Carlo Miniussi , Petro Julkunen , Marta Bortoletto

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引用次数: 0

Abstract

Background

Transcranial magnetic stimulation (TMS) combined with electroencephalography (EEG) can provide insight on cortical excitability and brain circuits. TMS-evoked potentials (TEPs) are phase-locked waveforms reflecting neural activity, with potential applications in psychiatry and neurology. However, the reliability of TEPs remains underexplored, hindering clinical standardization. This systematic review evaluates TEP reliability, focusing on commonly used measures and assessments.

Methods

A systematic review was conducted on PubMed for studies from 2002 to October 10, 2024, using keywords combining TMS, EEG, and reliability terms. Systematic reviews and non-English articles were excluded.

Results

Eighteen studies met inclusion criteria, mostly assessing young, healthy populations. Late TEP components demonstrated high relative reliability, while early components exhibited lower reliability and variability across sessions. Analytical methods like the intraclass and concordance correlation coefficients, and Pearson’s correlations consistently favored late TEPs.

Discussion

Late TEPs exhibit higher reliability, while early components require further research. TMS artifacts complicate interpretation, in both late and early responses. Formal reliability assessments, standardized protocols, and diverse populations are essential for advancing TEP reliability for clinical application.

Conclusions

A more comprehensive reliability assessments is needed before the implementation of clinical applications.

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.