A prospective controlled study of a wearable rhythmic vibrotactile device for tremor in Parkinson’s disease

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2025-02-07 DOI:10.1016/j.clinph.2025.02.255

F. Goltz , M.F. Dirkx , J.M. Schoffelen , M.S. Okun , W. Hu , C.W. Hess , J. Nonnekes , B.R. Bloem , R.C. Helmich

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引用次数: 0

Abstract

Objective

Tremor in Parkinson’s disease (PD) does not always respond to dopaminergic medication, therefore new treatment strategies are needed. Preliminary evidence has suggested that manipulation of peripheral afferents may reduce tremor amplitude, but existing research is inconclusive and has not been properly controlled. Here, we explored the effects of peripheral vibrotactile stimulation (ViS) on PD tremor using a within-subjects controlled design.

Methods

Thirty PD patients with clear tremor were included. ViS (open-loop) was applied to the most affected wrist. Four stimulation conditions were compared: tremor frequency (TF), 1.5*TF, 80 Hz stimulation, and sham. We tested the effect of these stimulation conditions on tremor power (measured with accelerometry) during three contexts: rest tremor, rest tremor during cognitive load, and postural tremor. Entrainment between tremor and stimulation was tested using complex phase-locking value (PLV).

Results

There were no significant effects on tremor power when ViS was applied. Stimulation effects did not depend on the context in which tremor occurred. PLVs showed that tremor phase was not influenced by ViS.

Conclusions

Open-loop ViS does not modulate PD tremor.

Significance

This study is one of the first controlled large sample studies to investigate how ViS may influence the objective measures of tremor in PD.

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.