A prospective controlled study of a wearable rhythmic vibrotactile device for tremor in Parkinson’s disease

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2025-02-07 DOI:10.1016/j.clinph.2025.02.255

F. Goltz , M.F. Dirkx , J.M. Schoffelen , M.S. Okun , W. Hu , C.W. Hess , J. Nonnekes , B.R. Bloem , R.C. Helmich

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Abstract

Objective

Tremor in Parkinson’s disease (PD) does not always respond to dopaminergic medication, therefore new treatment strategies are needed. Preliminary evidence has suggested that manipulation of peripheral afferents may reduce tremor amplitude, but existing research is inconclusive and has not been properly controlled. Here, we explored the effects of peripheral vibrotactile stimulation (ViS) on PD tremor using a within-subjects controlled design.

Methods

Thirty PD patients with clear tremor were included. ViS (open-loop) was applied to the most affected wrist. Four stimulation conditions were compared: tremor frequency (TF), 1.5*TF, 80 Hz stimulation, and sham. We tested the effect of these stimulation conditions on tremor power (measured with accelerometry) during three contexts: rest tremor, rest tremor during cognitive load, and postural tremor. Entrainment between tremor and stimulation was tested using complex phase-locking value (PLV).

Results

There were no significant effects on tremor power when ViS was applied. Stimulation effects did not depend on the context in which tremor occurred. PLVs showed that tremor phase was not influenced by ViS.

Conclusions

Open-loop ViS does not modulate PD tremor.

Significance

This study is one of the first controlled large sample studies to investigate how ViS may influence the objective measures of tremor in PD.

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一种可穿戴节律振动触觉装置治疗帕金森病震颤的前瞻性对照研究

目的：帕金森病（PD）震颤患者对多巴胺能药物治疗并不总是有效，因此需要新的治疗策略。初步证据表明，操纵外周传入神经可能会降低震颤振幅，但现有的研究尚无定论，也没有得到适当的控制。在这里，我们使用受试者控制设计探讨了外周振动触觉刺激（ViS）对PD震颤的影响。方法选取30例伴有明显震颤的PD患者。ViS（开环）应用于受影响最大的手腕。比较4种刺激条件：震颤频率（TF）、1.5*TF、80 Hz刺激和假手术。我们在三种情况下测试了这些刺激条件对震颤功率（用加速度计测量）的影响：静止震颤、认知负荷时的静止震颤和姿势性震颤。用复锁相值（PLV）测试震颤与刺激之间的夹带。结果ViS对震颤功率无明显影响。刺激的效果并不取决于震颤发生的环境。PLVs显示震颤相不受ViS的影响。结论开环ViS对PD震颤无调节作用。本研究是第一个研究ViS如何影响PD患者震颤客观指标的大样本对照研究之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.