A New BNiLi Glass Sample [Li2O-B2O3-NiO] Conjugated with Poly(l-alanine)-Modified Carbon Paste Electrode for the Electrochemical Determination of Linezolid

Abstract

A new glass sample (BNiLi) was prepared by melt-quenching method. The physical nature of the glass sample was investigated via X-ray diffraction, while the atomic structure was studied via density and infrared spectroscopy. The existence of main structure units such as \({\text{BO}}_{3}\) and \({\text{BO}}_{4}\) was confirmed. Furthermore, the optical absorbance was measured, and the electronic transitions of nickel ions were revealed. Optical band gap energy was estimated for the BNiLi glass sample. The prepared BNiLi glass was used to modify a carbon paste electrode (CPE) with a polymer film of l-alanine (Ala). The obtained p-Ala@BNiLi/CPE was employed to determine linezolid (LIN) by cyclic voltammetric, linear sweep voltammetric, differential pulse voltammetric, and chronoamperometric methods. The proposed sensor achieves a low limit of detection (0.23 nM), good repeatability, and high stability. The fabricated sensor was applied to detect LIN in pharmaceutical and human serum samples.

Graphical Abstract