Cyanidin-3-glucoside reduces cell migration and inflammatory profile of acute leukemia cells.

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED Natural Product Research Pub Date : 2025-02-05 DOI:10.1080/14786419.2025.2462116

Luciene Assaf, Edson Naoto Makyiama, Beatriz Almeida, Jeremias Martins de Almeida Junior, Carlos Eduardo da Silva Gonçalves, Sumara de Freitas, Rosana Lopes Rodrigues Amon, Bruna Roberta Oliveira Neves, Marcelo Macedo Rogero, Ricardo Ambrosio Fock

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Abstract

Anthocyanins, water-soluble flavonoids found in fruits and vegetables, exhibit diverse biological activities, with cyanidin being the most common pigment. While cyanidin's chemo preventive and -antioxidant activity is well-studied, its impact on inflammatory profile and migration capacity of leukemic cells are less understood. This study evaluates the effects of Cyanidin-3-glucoside (C3G) on the inflammatory mechanisms influencing leukemic cell migration. Results show that C3G doses up to 50 µM do not affect cell metabolism, viability, or cell cycle phases. C3G significantly reduces TNF-α, IL-8, CCL2 production, and the p-NFκB/NFκB ratio in LPS (Lipopolysaccharide)-challenged cells. It also diminishes migration rates in response to LPS or fMLP (N-formyl-methionyl-leucyl-phenylalanine) stimulation and reduces Rho-GTP expression. Thus, C3G modifies the inflammatory and migration properties of leukemic cells, highlighting the potential of anthocyanins as a complementary therapy and an avenue for further therapeutic intervention.

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花青素-3-葡萄糖苷减少急性白血病细胞的细胞迁移和炎症谱。

花青素是一种水溶性类黄酮，存在于水果和蔬菜中，具有多种生物活性，其中花青素是最常见的色素。虽然花青素的化学预防和抗氧化活性已被充分研究，但其对炎症特征和白血病细胞迁移能力的影响尚不清楚。本研究评估了花青素-3-葡萄糖苷（C3G）在影响白血病细胞迁移的炎症机制中的作用。结果表明，C3G剂量高达50µM不影响细胞代谢、活力或细胞周期阶段。C3G显著降低LPS（脂多糖）刺激细胞的TNF-α、IL-8、CCL2的产生和p-NFκB/NFκB比值。它还减少了对LPS或fMLP （n -甲酰-蛋氨酸-leucyl-苯丙氨酸）刺激的迁移率，并降低了Rho-GTP的表达。因此，C3G改变了白血病细胞的炎症和迁移特性，突出了花青素作为补充治疗和进一步治疗干预途径的潜力。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.