Alexander J. Bahnick , David Ruppert , Gabriella A. Krisanic , Jeffrey I. Everitt , Vance G. Fowler , Howard Levinson , Matthew L. Becker
{"title":"Bioresorbable Suture Anchor Clips for Soft Tissue Wound Repair","authors":"Alexander J. Bahnick , David Ruppert , Gabriella A. Krisanic , Jeffrey I. Everitt , Vance G. Fowler , Howard Levinson , Matthew L. Becker","doi":"10.1021/acs.biomac.4c01491","DOIUrl":null,"url":null,"abstract":"<div><div>Mesh suture is an emerging technology for closing high-tension soft tissue wounds. However, bulky mesh surgical knots can irritate surrounding tissue and harbor bacteria, leading to an increased risk of infection and palpability. Thus, a degradable knotless anchoring system is needed to secure mesh sutures. Here, novel anchor clip devices are fabricated <em>via</em> continuous liquid interface production (CLIP) three-dimensional (3D) printing using poly(propylene fumarate-<em>co</em>-propylene succinate) (PPFPS) oligomers. Thiol–ene cross-linking yields fully degradable thermoset devices with tunable mechanical properties. For comparison, high-resolution anchor clips are also fabricated <em>via</em> traditional injection molding using poly(<span>l</span>-lactide-<em>co</em>-glycolide) (PLGA). The PLGA anchor clips show similar mechanical performance to predicate soft tissue fixation techniques in a benchtop abdominal wall reconstruction model. Both PLGA and PPFPS anchor clips demonstrate satisfactory <em>in vivo</em> biocompatibility in a porcine abdominal implantation model. This work outlines the development of bioresorbable anchor clips for soft tissue fixation and illustrates their potential for clinical translation.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (163KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 3","pages":"Pages 1709-1724"},"PeriodicalIF":5.4000,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomacromolecules","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1525779725000704","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Mesh suture is an emerging technology for closing high-tension soft tissue wounds. However, bulky mesh surgical knots can irritate surrounding tissue and harbor bacteria, leading to an increased risk of infection and palpability. Thus, a degradable knotless anchoring system is needed to secure mesh sutures. Here, novel anchor clip devices are fabricated via continuous liquid interface production (CLIP) three-dimensional (3D) printing using poly(propylene fumarate-co-propylene succinate) (PPFPS) oligomers. Thiol–ene cross-linking yields fully degradable thermoset devices with tunable mechanical properties. For comparison, high-resolution anchor clips are also fabricated via traditional injection molding using poly(l-lactide-co-glycolide) (PLGA). The PLGA anchor clips show similar mechanical performance to predicate soft tissue fixation techniques in a benchtop abdominal wall reconstruction model. Both PLGA and PPFPS anchor clips demonstrate satisfactory in vivo biocompatibility in a porcine abdominal implantation model. This work outlines the development of bioresorbable anchor clips for soft tissue fixation and illustrates their potential for clinical translation.
期刊介绍：
Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine.
Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.
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