The Role of Dietary Protein in Mitigating the Risk of Nonalcoholic Fatty Liver Disease.

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a prevalent liver disease, mainly associated with excessive accumulation of fat in the liver. It has become a global health concern. The diagnosis of NAFLD is often done through liver biopsy; however, noninvasive methods have their own advantages. Dietary intervention, especially increased dietary protein alongside managing overall body weight, have been shown to be a promising strategy to lessen the impact of NAFLD. Dietary protein has been shown to reduce fat accumulation in the liver by increasing liver metabolism, eliciting satiety, improving insulin sensitivity, and enhancing muscle mass retention, collectively aiding in weight management. Both animal and plant proteins have benefits; however, plant proteins have demonstrated more metabolic advantages, while animal proteins have more downsides. Bridging the protein gap is critical, particularly in areas with limited availability to high-quality protein or in populations where dietary protein intake is inadequate. This commentary highlights the importance of obtaining sufficient protein from readily available and sustainable food sources. Furthermore, diets high in protein, like the Mediterranean diet, have proven to delay the advancement and likelihood of NAFLD. In conclusion, adequate dietary protein plays a crucial part in diminishing the risk of NAFLD, and efforts in public health should concentrate on addressing protein deficiency to decrease the growing burden of liver disease.