Association of chronic pain with frailty and pre-frailty in older adults: A systematic review and meta-analysis

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY Archives of gerontology and geriatrics Pub Date : 2025-02-11 DOI:10.1016/j.archger.2025.105784

Shenbi Yang , Hongyan Wang , Yanmin Tao , Jing Tian , Zhifei Wen , Jun Cao , Wen Zhang , Sihan Peng , Xiangeng Zhang

{"title":"Association of chronic pain with frailty and pre-frailty in older adults: A systematic review and meta-analysis","authors":"Shenbi Yang , Hongyan Wang , Yanmin Tao , Jing Tian , Zhifei Wen , Jun Cao , Wen Zhang , Sihan Peng , Xiangeng Zhang","doi":"10.1016/j.archger.2025.105784","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><div>Frailty has been demonstrated to correlate with chronic pain (CP). This study aimed to estimate the risk of frailty/pre-frailty and evaluate the potential bidirectional relationship between frailty/pre-frailty and CP.</div></div><div><h3>Methods</h3><div>A systematic search was conducted across ten databases, covering literature from their inception through November 23, 2024. Two independent reviewers screened relevant studies, assessed study quality, and extracted data. All analyses were performed using R software, version 4.3.1.</div></div><div><h3>Results</h3><div>A total of 25,904 participants aged ≥ 60 years were included in 33 studies. CP significantly increased the risk of frailty (OR = 1.91, 95 % CI: 1.47–2.47; <em>I<sup>2</sup></em> = 82 %, <em>p</em> < 0.01), whereas no significant association was found between frailty/pre-frailty and CP risk (OR = 1.52, 95 % CI: 0.66–3.50; <em>I<sup>2</sup></em> = 98 %, <em>p</em> < 0.01). Eleven studies were classified as high quality, and the remainder as moderate quality.</div></div><div><h3>Conclusions</h3><div>No evidence supports a bidirectional relationship between frailty/pre-frailty and CP. Nonetheless, addressing and managing CP in older adults may mitigate the risk of frailty and promote healthy aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105784"},"PeriodicalIF":3.5000,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of gerontology and geriatrics","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167494325000421","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose

Frailty has been demonstrated to correlate with chronic pain (CP). This study aimed to estimate the risk of frailty/pre-frailty and evaluate the potential bidirectional relationship between frailty/pre-frailty and CP.

Methods

A systematic search was conducted across ten databases, covering literature from their inception through November 23, 2024. Two independent reviewers screened relevant studies, assessed study quality, and extracted data. All analyses were performed using R software, version 4.3.1.

Results

A total of 25,904 participants aged ≥ 60 years were included in 33 studies. CP significantly increased the risk of frailty (OR = 1.91, 95 % CI: 1.47–2.47; I² = 82 %, p < 0.01), whereas no significant association was found between frailty/pre-frailty and CP risk (OR = 1.52, 95 % CI: 0.66–3.50; I² = 98 %, p < 0.01). Eleven studies were classified as high quality, and the remainder as moderate quality.

Conclusions

No evidence supports a bidirectional relationship between frailty/pre-frailty and CP. Nonetheless, addressing and managing CP in older adults may mitigate the risk of frailty and promote healthy aging.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

求助全文

约1分钟内获得全文去求助

来源期刊

Archives of gerontology and geriatrics 医学-老年医学

CiteScore

7.30

自引率

5.00%

发文量

198

审稿时长

16 days

期刊介绍： Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.