Association of chronic pain with frailty and pre-frailty in older adults: A systematic review and meta-analysis

IF 3.8 3区医学 Q2 GERIATRICS & GERONTOLOGY Archives of gerontology and geriatrics Pub Date : 2025-04-01 Epub Date: 2025-02-11 DOI:10.1016/j.archger.2025.105784

Shenbi Yang , Hongyan Wang , Yanmin Tao , Jing Tian , Zhifei Wen , Jun Cao , Wen Zhang , Sihan Peng , Xiangeng Zhang

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Abstract

Purpose

Frailty has been demonstrated to correlate with chronic pain (CP). This study aimed to estimate the risk of frailty/pre-frailty and evaluate the potential bidirectional relationship between frailty/pre-frailty and CP.

Methods

A systematic search was conducted across ten databases, covering literature from their inception through November 23, 2024. Two independent reviewers screened relevant studies, assessed study quality, and extracted data. All analyses were performed using R software, version 4.3.1.

Results

A total of 25,904 participants aged ≥ 60 years were included in 33 studies. CP significantly increased the risk of frailty (OR = 1.91, 95 % CI: 1.47–2.47; I² = 82 %, p < 0.01), whereas no significant association was found between frailty/pre-frailty and CP risk (OR = 1.52, 95 % CI: 0.66–3.50; I² = 98 %, p < 0.01). Eleven studies were classified as high quality, and the remainder as moderate quality.

Conclusions

No evidence supports a bidirectional relationship between frailty/pre-frailty and CP. Nonetheless, addressing and managing CP in older adults may mitigate the risk of frailty and promote healthy aging.

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老年人慢性疼痛与虚弱和虚弱前期的关系：系统回顾和荟萃分析

目的：虚弱已被证明与慢性疼痛（CP）相关。本研究旨在评估脆弱性/前期脆弱性的风险，并评估脆弱性/前期脆弱性与cp之间潜在的双向关系。方法系统检索10个数据库，涵盖从建立到2024年11月23日的文献。两名独立审稿人筛选了相关研究，评估了研究质量，并提取了数据。所有分析均使用R软件4.3.1版进行。结果33项研究共纳入25904名年龄≥60岁的受试者。CP显著增加虚弱的风险(OR = 1.91, 95% CI: 1.47-2.47；I2 = 82%, p <；0.01)，而衰弱/衰弱前与CP风险之间无显著关联(OR = 1.52, 95% CI: 0.66-3.50；I2 = 98%, p <；0.01)。11项研究被归类为高质量，其余为中等质量。结论：没有证据支持衰弱/衰弱前期与CP之间的双向关系。尽管如此，处理和管理老年人的CP可能会减轻衰弱的风险，促进健康老龄化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of gerontology and geriatrics 医学-老年医学

CiteScore

7.30

自引率

5.00%

发文量

198

审稿时长

16 days

期刊介绍： Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.