Sara Koynov , Kristen Duda , Plinio A. De los Santos , David J. Goldfarb
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引用次数: 0
Abstract
The method of shear cell testing plays a pivotal role in assessing the flowability of powders, notably in the context of evaluating pharmaceutical formulations and processes. Despite numerous studies on shear cell methodology and its diverse applications, there remains a need to compare the performance of specific shear cell designs. This study addresses this gap by offering a comprehensive comparison of two full-bed rotational shear cells – the Peschl and FT4 cells. The evaluation focuses on assessing the precision and accuracy of each instrument, considering six materials: two reference materials with well-established behavior and four pharmaceutically relevant materials. Key parameters obtained from the measured yield loci were analyzed and compared, shedding light on the differences in performance between the two shear cells. Statistical analysis using regression methods revealed the significance of not only the test material but also the shear cell used for measurement, emphasizing the influential role of shear cell design. Additionally, this work delves into the significance of powder bed density during shear cell measurements and its broader implications for comprehensive powder characterization, providing valuable insights for the field of material science and pharmaceutical formulation.
期刊介绍：
Powder Technology is an International Journal on the Science and Technology of Wet and Dry Particulate Systems. Powder Technology publishes papers on all aspects of the formation of particles and their characterisation and on the study of systems containing particulate solids. No limitation is imposed on the size of the particles, which may range from nanometre scale, as in pigments or aerosols, to that of mined or quarried materials. The following list of topics is not intended to be comprehensive, but rather to indicate typical subjects which fall within the scope of the journal's interests:
Formation and synthesis of particles by precipitation and other methods.
Modification of particles by agglomeration, coating, comminution and attrition.
Characterisation of the size, shape, surface area, pore structure and strength of particles and agglomerates (including the origins and effects of inter particle forces).
Packing, failure, flow and permeability of assemblies of particles.
Particle-particle interactions and suspension rheology.
Handling and processing operations such as slurry flow, fluidization, pneumatic conveying.
Interactions between particles and their environment, including delivery of particulate products to the body.
Applications of particle technology in production of pharmaceuticals, chemicals, foods, pigments, structural, and functional materials and in environmental and energy related matters.
For materials-oriented contributions we are looking for articles revealing the effect of particle/powder characteristics (size, morphology and composition, in that order) on material performance or functionality and, ideally, comparison to any industrial standard.
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