Manipulation of Surface Potential Distribution Enhances Osteogenesis by Promoting Pro-Angiogenic Macrophage Polarization via Activation of the PI3K-Akt Signaling Pathway (Adv. Sci. 8/2025)

IF 14.3 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Advanced Science Pub Date : 2025-02-24 DOI:10.1002/advs.202570045

Qun Cui, Xiaona Zheng, Yunyang Bai, Yaru Guo, Shuo Liu, Yanhui Lu, Lulu Liu, Jia Song, Yang Liu, Boon Chin Heng, Fuping You, Mingming Xu, Xuliang Deng, Xuehui Zhang

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Abstract

Microscopic Electrical Signals and Bone Regeneration

Fuping You, Mingming Xu, Xuehui Zhang, and co-workers discover a novel insight into how electrical signals at the micro- and nanoscale regulate immune cells to promote bone regeneration. This cover illustration uses the electrically charged cartoon characters to represent macrophages activated by electrical signals. The heterogeneous electrical signals provided by the membrane activate macrophages into a pro-angiogenic phenotype, thereby enhancing angiogenesis and accelerating bone defect repair. More details can be found in article number 2414278.

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.